SCHEMBL3704183

SCHEMBL3704183

Cc1cc2cc(C(N)=S)ccc2[nH]1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 1/20 0.55
KEAP1 Q14145 1/20 0.55
AXL P30530 1/20 0.47
LMNA P02545 2/20 0.47
MAPT P10636 3/20 0.46
MAOA P21397 2/20 0.43
MAOB P27338 2/20 0.43
MMP2 P08253 1/20 0.42
MMP13 P45452 1/20 0.42
ALDH1A1 P00352 2/20 0.42
KDM4E B2RXH2 1/20 0.42
SMN1; SMN2 Q16637 2/20 0.42
ALOX12 P18054 1/20 0.42
MEN1 O00255 1/20 0.41
KMT2A Q03164 1/20 0.41
F2 P00734 2/20 0.40
F10 P00742 2/20 0.40
PLG P00747 2/20 0.40
PLAU P00749 2/20 0.40
PRSS1 P07477 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7891159 0.84 CYP2A6 (0.52) CYP2A6KEAP1AXLLMNAMAPT
SCHEMBL3710973 0.82 MMP2 (0.60) CYP2A6KEAP1AXLMAPTMAOA
SCHEMBL7906683 0.82 F2 (0.58) CYP2A6KEAP1F2F10PLG
SCHEMBL13267581 0.76 MAOB (0.55) CYP2A6KEAP1AXLMAPTMAOA
SCHEMBL1105989 0.76 HRH3 (0.59) CYP2A6KEAP1AXLMAPTMAOA
SCHEMBL12958495 0.76 CYP2A6 (0.52) CYP2A6KEAP1AXLLMNAMAPT
SCHEMBL10143894 0.76 CYP2A6 (0.52) CYP2A6KEAP1AXLLMNAMAPT
SCHEMBL25139676 0.72 KDM4E (0.51) CYP2A6KEAP1AXLLMNAMAPT
SCHEMBL19058581 0.72 MAOA (0.57) CYP2A6KEAP1LMNAMAPTMAOA
SCHEMBL8149140 0.72 CYP2A6 (0.47) CYP2A6KEAP1AXLLMNAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010093191-A2 NOVEL COMPOUNDS EFFECTIVE AS XANTHINE OXIDASE INHIBITORS, METHOD FOR PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME LG LIFE SCIENCES LTD. (KR) 2010-08-19 WO disclosed
WO-2010093191-A2 NOVEL COMPOUNDS EFFECTIVE AS XANTHINE OXIDASE INHIBITORS, METHOD FOR PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME LG LIFE SCIENCES LTD. (KR) 2010-08-19 WO disclosed