Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 12/20 | 0.67 |
| ▸ | NPC1 | O15118 | 10/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.67 |
| ▸ | ATM | Q13315 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.65 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.65 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.65 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.65 |
| ▸ | TP53 | P04637 | 1/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 3/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | NAMPT | P43490 | 5/20 | 0.60 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3696337 | 1.00 | RAB9A (0.67) | RAB9ANPC1SMN1; SMN2KMT2AATM | |
| SCHEMBL3698236 | 0.83 | NAMPT (0.84) | RAB9ANPC1SMN1; SMN2KMT2AATM | |
| SCHEMBL3704298 | 0.80 | RAB9A (0.69) | RAB9ANPC1SMN1; SMN2KMT2AATM | |
| SCHEMBL3709189 | 0.80 | NAMPT (0.84) | RAB9ANPC1SMN1; SMN2KMT2AATM | |
| SCHEMBL5522728 | 0.79 | RAB9A (1.00) | RAB9ANPC1SMN1; SMN2KMT2AATM | |
| SCHEMBL3707242 | 0.79 | RAB9A (0.73) | RAB9ANPC1SMN1; SMN2KMT2AATM | |
| SCHEMBL10226339 | 0.79 | RAB9A (1.00) | RAB9ANPC1SMN1; SMN2KMT2AATM | |
| SCHEMBL30515325 | 0.79 | RAB9A (1.00) | RAB9ANPC1SMN1; SMN2KMT2AATM | |
| SCHEMBL3701097 | 0.78 | RAB9A (0.66) | RAB9ANPC1SMN1; SMN2KMT2AATM | |
| SCHEMBL3699815 | 0.78 | RAB9A (0.66) | RAB9ANPC1SMN1; SMN2KMT2AATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2640704-A1 | NAMPT INHIBITORS | Abbvie Inc. (US) | 2013-09-25 | — | — | EP | claimed |
| WO-2012067963-A1 | NAMPT INHIBITORS | ABBOTT LABORATORIES (US) | 2012-05-24 | — | — | WO | claimed |
| US-20120122924-A1 | NAMPT INHIBITORS | ABBOTT LABORATORIES (US) | 2012-05-17 | — | — | US | claimed |
| EP-2640704-A1 | NAMPT INHIBITORS | Abbvie Inc. (US) | 2013-09-25 | — | — | EP | disclosed |
| WO-2012067963-A1 | NAMPT INHIBITORS | ABBOTT LABORATORIES (US) | 2012-05-24 | — | — | WO | disclosed |
| US-20120122924-A1 | NAMPT INHIBITORS | ABBOTT LABORATORIES (US) | 2012-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120122924-A1 | NAMPT INHIBITORS | NAMPT, NNMT, NAPRT | RAB9A 2177/4885NPC1 88/4885SMN1; SMN2 334/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.