Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ethambutol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC3 | O15438 | 1/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 0.94 |
| ▸ | CNR1 | P21554 | 1/20 | 0.94 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.94 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.94 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.94 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | MMP1 | P03956 | 1/20 | 0.30 |
| ▸ | MMP2 | P08253 | 1/20 | 0.30 |
| ▸ | MMP8 | P22894 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethambutol SCHEMBL3398 | 1.00 | ABCC3 (1.00) | ABCC3SMN1; SMN2LMNACNR1ADRA1A | |
| Ethambutol SCHEMBL27583822 | 1.00 | ABCC3 (1.00) | ABCC3SMN1; SMN2LMNACNR1ADRA1A | |
| Ethambutol SCHEMBL3026481 | 1.00 | ABCC3 (1.00) | ABCC3SMN1; SMN2LMNACNR1ADRA1A | |
| Ethambutol SCHEMBL3400 | 1.00 | ABCC3 (1.00) | ABCC3SMN1; SMN2LMNACNR1ADRA1A | |
| Ethambutol SCHEMBL650049 | 1.00 | ABCC3 (1.00) | ABCC3SMN1; SMN2LMNACNR1ADRA1A | |
| Ethambutol SCHEMBL9949005 | 1.00 | ABCC3 (1.00) | ABCC3SMN1; SMN2LMNACNR1ADRA1A | |
| Ethambutol SCHEMBL2636850 | 0.97 | LMNA (1.00) | ABCC3SMN1; SMN2LMNACNR1ADRA1A | |
| Ethambutol SCHEMBL15479016 | 0.97 | LMNA (1.00) | ABCC3SMN1; SMN2LMNACNR1ADRA1A | |
| Ethambutol SCHEMBL3399 | 0.97 | LMNA (1.00) | ABCC3SMN1; SMN2LMNACNR1ADRA1A | |
| Ethambutol SCHEMBL2961583 | 0.97 | LMNA (1.00) | ABCC3SMN1; SMN2LMNACNR1ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 6446 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260027140-A1 | COMPOSITIONS AND METHODS FOR TREATING AND AMELIORATING RESPIRATORY CONDITIONS AND INFLAMMATION OF MUCOSA | ATOPIC MEDICAL INC (US) | 2026-01-29 | — | — | US | claimed |
| EP-4646109-A2 | NATURAL LIPID PARTICLE FORMULATIONS FOR AGRICULTURAL APPLICATIONS | Invaio Sciences, Inc. (US) | 2025-11-12 | — | — | EP | claimed |
| US-12163142-B2 | Methods for manufacturing plant messenger packs | FLAGSHIP PIONEERING INNOVATIONS VI, LLC (US) | 2024-12-10 | — | — | US | claimed |
| WO-2024168193-A2 | NATURAL LIPID PARTICLE FORMULATIONS FOR AGRICULTURAL APPLICATIONS | INVAIO SCIENCES, INC. (US) | 2024-08-15 | — | — | WO | claimed |
| US-20240238295-A1 | METHOD FOR MODULATING NEUROPATHIES | CHENGDU WENDING TECHNOLOGY DEVELOPMENT CO., LTD (CN) | 2024-07-18 | — | — | US | claimed |
| CN-118304388-A | Application of TAK1 in preparation of medicines for treating peripheral nerve injury | 南通大学 | 2024-07-09 | — | — | CN | claimed |
| CN-118207284-A | Mesenchymal stem cell immunity regulation capability and detection method thereof | 博雅干细胞科技有限公司 | 2024-06-18 | — | — | CN | claimed |
| EP-4380673-A1 | WEARABLE NEUROSTIMULATION SYSTEM | Cala Health, Inc. (US) | 2024-06-12 | — | — | EP | claimed |
| US-11986645-B2 | Restless legs syndrome treatment system | NEUROSTIM TECHNOLOGIES LLC (US) | 2024-05-21 | — | — | US | claimed |
| EP-4366820-A1 | PERSONALIZED THERAPY NEUROSTIMULATION SYSTEMS | Cala Health, Inc. (US) | 2024-05-15 | — | — | EP | claimed |
| CN-1136334-A | Device and method for shaping pantyhose and shaped pantyhose | KREMPEL AUGUST SOEHNE (DE) | 1996-11-20 | — | — | CN | claimed |
| CN-1134278-A | Aerosol for preventing and curing pulmonary tuberculosis and its preparing method and synergy method | CONG FANZI (CN) | 1996-10-30 | — | — | CN | claimed |
| WO-1995022457-A1 | CLOSABLE BAG AND METHOD OF MAKING SAME | CLARK DONALD (US) | 1995-08-24 | — | — | WO | claimed |
| CN-1105236-A | Aerosol for preventing transmission and curing of lung tuberculosis and preparing process thereof | CONG FANZI (CN) | 1995-07-19 | — | — | CN | claimed |
| EP-0592410-A1 | A VALVE PROSTHESIS FOR IMPLANTATION IN THE BODY AND A CATHETER FOR IMPLANTATING SUCH VALVE PROSTHESIS. | ANDERSEN HENNING RUD (DK) | 1994-04-20 | — | — | EP | claimed |
| WO-1992003536-A1 | AUTOTRANSPLANTATION OF SCHWANN CELLS TO PROMOTE NERVOUS SYSTEM REPAIR | UNIVERSITY OF MIAMI AND ITS SCHOOL OF MEDICINE (US) | 1992-03-05 | — | — | WO | claimed |
| WO-1991017720-A1 | A VALVE PROSTHESIS FOR IMPLANTATION IN THE BODY AND A CATHETER FOR IMPLANTATING SUCH VALVE PROSTHESIS | ANDERSEN HENNING RUD (DK) | 1991-11-28 | — | — | WO | claimed |
| US-5053145-A | Dual direction transfer system for tramp oil collection | ELLISON BILLY L (US) | 1991-10-01 | — | — | US | claimed |
| US-4720456-A | Trehalose lipid tetraesters | WINTERSHALL AG (DE) | 1988-01-19 | — | — | US | claimed |
| US-RE29588-E | Preparation of d-2-amino-1-butanol salts | AMERICAN CYANAMID COMPANY (US) | 1978-03-21 | — | — | US | claimed |