Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ethambutol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC3 | O15438 | 1/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 0.94 |
| ▸ | CNR1 | P21554 | 1/20 | 0.94 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.94 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.94 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.94 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | MMP1 | P03956 | 1/20 | 0.30 |
| ▸ | MMP2 | P08253 | 1/20 | 0.30 |
| ▸ | MMP8 | P22894 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethambutol SCHEMBL3398 | 1.00 | ABCC3 (1.00) | ABCC3SMN1; SMN2LMNACNR1ADRA1A | |
| Ethambutol SCHEMBL27583822 | 1.00 | ABCC3 (1.00) | ABCC3SMN1; SMN2LMNACNR1ADRA1A | |
| Ethambutol SCHEMBL3026481 | 1.00 | ABCC3 (1.00) | ABCC3SMN1; SMN2LMNACNR1ADRA1A | |
| Ethambutol SCHEMBL3400 | 1.00 | ABCC3 (1.00) | ABCC3SMN1; SMN2LMNACNR1ADRA1A | |
| Ethambutol SCHEMBL650049 | 1.00 | ABCC3 (1.00) | ABCC3SMN1; SMN2LMNACNR1ADRA1A | |
| Ethambutol SCHEMBL37049 | 1.00 | ABCC3 (1.00) | ABCC3SMN1; SMN2LMNACNR1ADRA1A | |
| Ethambutol SCHEMBL2636850 | 0.97 | LMNA (1.00) | ABCC3SMN1; SMN2LMNACNR1ADRA1A | |
| Ethambutol SCHEMBL15479016 | 0.97 | LMNA (1.00) | ABCC3SMN1; SMN2LMNACNR1ADRA1A | |
| Ethambutol SCHEMBL3399 | 0.97 | LMNA (1.00) | ABCC3SMN1; SMN2LMNACNR1ADRA1A | |
| Ethambutol SCHEMBL2961583 | 0.97 | LMNA (1.00) | ABCC3SMN1; SMN2LMNACNR1ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2782921-B1 | ORGANIC TUNGSTEN COMPLEXES | VANDERBILT CHEMICALS LLC (US) | 2018-05-02 | — | — | EP | disclosed |
| US-8669386-B2 | Organic tungsten complexes | VANDEBILT CHEMICALS, LLC (US) | 2014-03-11 | — | — | US | disclosed |
| US-20120165563-A1 | ORGANIC TUNGSTEN COMPLEXES | R.T. VANDERBILT COMPANY, INC. | 2012-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120165563-A1 | ORGANIC TUNGSTEN COMPLEXES | ADH5, ELOVL5, ALOX5 | ABCC3 4627/4885SMN1; SMN2 3450/4885LMNA 4555/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.