Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | VKORC1 | Q9BQB6 | 2/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.30 |
| ▸ | AR | P10275 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL928102 | 0.89 | ABCG2 (0.32) | ABCB1 | |
| Hydrochloric Acid SCHEMBL926191 | 0.84 | KDM4E (0.39) | KDM4EMAPTMEN1CA12CA1 | |
| SCHEMBL926119 | 0.82 | KDM4E (0.40) | KDM4EMAPTMEN1CA12CA1 | |
| Hydrochloric Acid SCHEMBL926419 | 0.81 | KDM4E (0.35) | KDM4EMAPTMEN1CA12CA1 | |
| SCHEMBL7666892 | 0.80 | SNCA (0.45) | KDM4EMAPTMEN1LMNAKMT2A | |
| SCHEMBL7662615 | 0.79 | CA12 (0.38) | KDM4EMAPTMEN1CA12CA1 | |
| SCHEMBL7666098 | 0.78 | MAPT (0.58) | KDM4EMAPTMEN1CA12CA1 | |
| SCHEMBL7654027 | 0.78 | MAOA (0.37) | KDM4EMAPTMEN1CA12KMT2A | |
| SCHEMBL7664375 | 0.76 | MAPT (0.43) | KDM4EMAPTMEN1CA12TP53 | |
| SCHEMBL7656081 | 0.76 | MAPT (0.48) | KDM4EMAPTMEN1CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2268628-B1 | 2-ARYL AND 2 -HETEROARYL 4H-1-BENZOPYRAN-4-ONE-6-AMIDINO DERIVATIVES FOR THE TREATMENT OF ARTHRITIS, CANCER AND RELATED PAIN | ROTTAPHARM SPA (IT) | 2012-05-16 | — | — | EP | disclosed |