Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1G | O43497 | 3/20 | 0.41 |
| ▸ | CACNA1H | O95180 | 3/20 | 0.41 |
| ▸ | CACNA1I | Q9P0X4 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.38 |
| ▸ | BCL2A1 | Q16548 | 3/20 | 0.38 |
| ▸ | KLKB1 | P03952 | 5/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL369326 | 0.89 | CACNA1G (0.40) | CACNA1GCACNA1HCACNA1IKMT2AALDH1A1 | |
| SCHEMBL370155 | 0.84 | KMT2A (0.44) | CACNA1GCACNA1HCACNA1IKMT2ASMN1; SMN2 | |
| SCHEMBL370874 | 0.78 | FLT3 (0.42) | CACNA1GCACNA1HCACNA1IKMT2AALDH1A1 | |
| SCHEMBL370630 | 0.77 | PKM (0.41) | CACNA1GCACNA1HCACNA1IKMT2AALDH1A1 | |
| SCHEMBL369528 | 0.76 | KMT2A (0.43) | CACNA1GCACNA1HCACNA1IKMT2AAADAT | |
| SCHEMBL6837432 | 0.76 | KMT2A (0.41) | CACNA1GCACNA1HCACNA1IKMT2AALDH1A1 | |
| SCHEMBL369787 | 0.75 | KMT2A (0.39) | CACNA1GCACNA1HCACNA1IKMT2ASMN1; SMN2 | |
| SCHEMBL369161 | 0.75 | KMT2A (0.41) | CACNA1GCACNA1HCACNA1IKMT2AALDH1A1 | |
| SCHEMBL370205 | 0.75 | KMT2A (0.40) | CACNA1GCACNA1HCACNA1IKMT2AALDH1A1 | |
| SCHEMBL370149 | 0.74 | CACNA1G (0.34) | CACNA1GCACNA1HCACNA1IKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765091-B2 | Tetrahydropyrazolo [3,4-b] azepine derivatives and their use as allosteric modulators of metabotropic glutamate receptors | ADDEX PHARMA S.A. (CH) | 2017-09-19 | — | — | US | disclosed |
| EP-2592932-B1 | NOVEL TETRAHYDROPYRAZOLO[3,4-B]AZEPINE DERIVATIVES AND THEIR USE AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ADDEX PHARMA SA (CH) | 2016-01-20 | — | — | EP | disclosed |
| US-20130267499-A1 | NOVEL TETRAHYDROPYRAZOLO [3,4-b] AZEPINE DERIVATIVES AND THEIR USE AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ADDEX PHARMA SA (CH) | 2013-10-10 | — | — | US | disclosed |
| EP-2592932-A2 | NOVEL TETRAHYDROPYRAZOLO[3,4-B]AZEPINE DERIVATIVES AND THEIR USE AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Addex Pharma SA (CH) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012009001-A2 | NOVEL TETRAHYDROPYRAZOLO[3,4-B]AZEPINE DERIVATIVES AND THEIR USE AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ADDEX PHARMA S.A. (CH) | 2012-01-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130267499-A1 | NOVEL TETRAHYDROPYRAZOLO [3,4-b] AZEPINE DERIVATIVES AND THEIR USE AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | GRM4, GRM1, GRIK4 | CACNA1G 404/4885CACNA1H 447/4885CACNA1I 313/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.