SCHEMBL3705863

SCHEMBL3705863

COc1cc(OCCCO[Si](C)(C)C(C)(C)C)ccc1Cc1c(C)nc(N)nc1O

nearest known ligand 0.43

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TLR7 Q9NYK1 12/20 0.43
DHFR P00374 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16624352 0.89 DHFR (0.39) TLR7DHFR
SCHEMBL3705700 0.86 TLR7 (0.47) TLR7
SCHEMBL16626811 0.85 TLR7 (0.51) TLR7
SCHEMBL8547814 0.85 TLR7 (0.43) TLR7DHFR
Hydrochloric Acid SCHEMBL15391267 0.84 TLR7 (0.51) TLR7
SCHEMBL3701137 0.83 TLR7 (0.60) TLR7
SCHEMBL3699875 0.82 TLR7 (0.51) TLR7
SCHEMBL15393082 0.82 DHFR (0.37) TLR7DHFR
SCHEMBL853422 0.81 TLR7 (0.38) TLR7DHFR
SCHEMBL16616705 0.81 TLR7 (0.69) TLR7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12077510-B2 Carboxylic acid compounds Sumitomo Pharma Co., Ltd. (JP) 2024-09-03 US disclosed
US-20220267282-A1 CARBOXYLIC ACID COMPOUNDS SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) 2022-08-25 US disclosed
US-11299465-B2 Carboxylic acid compounds SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) 2022-04-12 US disclosed
US-11299465-B2 Carboxylic acid compounds SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) 2022-04-12 US disclosed
US-20200317623-A1 CARBOXYLIC ACID COMPOUNDS SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) 2020-10-08 US disclosed
US-20200317623-A1 CARBOXYLIC ACID COMPOUNDS SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) 2020-10-08 US disclosed
US-10562861-B2 Carboxylic acid compounds SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) 2020-02-18 US disclosed
US-10562861-B2 Carboxylic acid compounds SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) 2020-02-18 US disclosed
US-20190119220-A1 CARBOXYLIC ACID COMPOUNDS SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) 2019-04-25 US disclosed
US-20190119220-A1 CARBOXYLIC ACID COMPOUNDS SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) 2019-04-25 US disclosed
US-9533978-B2 Pyrimidine derivatives and their use in the treatment of cancer and further diseases SUMITOMO DAINIPPON PHARMA CO., LTD (JP) 2017-01-03 US disclosed
US-20160251319-A1 CARBOXYLIC ACID COMPOUNDS SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) 2016-09-01 US disclosed
US-20160251319-A1 CARBOXYLIC ACID COMPOUNDS SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) 2016-09-01 US disclosed
US-9376398-B2 Carboxylic acid compounds SUMITOMO DAINIPPON PHARMA CO., LTD (JP) 2016-06-28 US disclosed
US-9376398-B2 Carboxylic acid compounds SUMITOMO DAINIPPON PHARMA CO., LTD (JP) 2016-06-28 US disclosed
US-20150099770-A1 CARBOXYLIC ACID COMPOUNDS Sumitomo Pharma Co., Ltd. (JP) 2015-04-09 US disclosed
US-20150099770-A1 CARBOXYLIC ACID COMPOUNDS Sumitomo Pharma Co., Ltd. (JP) 2015-04-09 US disclosed
US-20150080396-A1 Novel Pyrimidine Derivatives and Their Use in the Treatment of Cancer and Further Diseases DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) 2015-03-19 US disclosed
WO-2012066335-A1 PHENOL COMPOUNDS ALS TOLL -LIKE RECEPTOR 7 AGONISTS ASTRAZENECA AB (SE) 2012-05-24 WO disclosed
US-20120122867-A1 NOVEL PYRIMIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CANCER AND FURTHER DISEASES ASTRAZENECA UK LIMITED (GB) 2012-05-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150099770-A1 CARBOXYLIC ACID COMPOUNDS C9, SUCNR1, C3AR1 TLR7 87/4885DHFR 1267/4885
US-20160251319-A1 CARBOXYLIC ACID COMPOUNDS C9, SUCNR1, C3AR1 TLR7 87/4885DHFR 1267/4885
US-20120122867-A1 NOVEL PYRIMIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CANCER AND FURTHER DISEASES TYMS, TYMP, DPYD TLR7 2123/4885DHFR 19/4885
US-12077510-B2 Carboxylic acid compounds C9, C3AR1, SUCNR1 TLR7 79/4885DHFR 1434/4885
US-20200317623-A1 CARBOXYLIC ACID COMPOUNDS C9, C3AR1, SUCNR1 TLR7 79/4885DHFR 1434/4885
US-20190119220-A1 CARBOXYLIC ACID COMPOUNDS C9, C3AR1, SUCNR1 TLR7 79/4885DHFR 1434/4885
US-11299465-B2 Carboxylic acid compounds C9, C3AR1, SUCNR1 TLR7 79/4885DHFR 1434/4885
US-20150080396-A1 Novel Pyrimidine Derivatives and Their Use in the Treatment of Cancer and Further Diseases TYMS, TYMP, DPYD TLR7 2123/4885DHFR 19/4885
US-20220267282-A1 CARBOXYLIC ACID COMPOUNDS C9, C3AR1, SUCNR1 TLR7 79/4885DHFR 1434/4885
US-10562861-B2 Carboxylic acid compounds C9, C3AR1, SUCNR1 TLR7 79/4885DHFR 1434/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.