Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.53 |
| ▸ | AXL | P30530 | 1/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 3/20 | 0.31 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18819885 | 0.80 | CYP2A6 (0.42) | DYRK1AAXLMKNK1MKNK2CYP2A6 | |
| SCHEMBL11011064 | 0.77 | DYRK1A (0.37) | DYRK1ACYP2A6KDM4EMALT1ALDH1A1 | |
| SCHEMBL14299159 | 0.72 | CYP2A6 (0.42) | DYRK1AAXLMKNK1MKNK2CYP2A6 | |
| SCHEMBL1493848 | 0.71 | DYRK1A (0.43) | DYRK1AKDM4EALDH1A1CYP2C19POLB | |
| SCHEMBL25841258 | 0.71 | DYRK1A (0.42) | DYRK1AAXLMKNK1MKNK2ALDH1A1 | |
| SCHEMBL10480000 | 0.70 | SMN1; SMN2 (0.36) | DYRK1AKDM4EALDH1A1POLBMAPT | |
| SCHEMBL18876005 | 0.69 | DYRK1A (0.40) | DYRK1AAXLMKNK1MKNK2CYP2A6 | |
| SCHEMBL20805577 | 0.69 | DYRK1A (0.37) | DYRK1ACYP2A6KDM4EALDH1A1MAPT | |
| SCHEMBL6684473 | 0.69 | DYRK1A (0.44) | DYRK1AAXLMKNK1MKNK2CYP2A6 | |
| SCHEMBL5333350 | 0.69 | KDM4E (0.50) | DYRK1AAXLCYP2A6KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593457-A1 | PYRAZOLO [1, 5A]PYRIMIDINE AND THIENO [3, 2B]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | F.HOFFMANN-LA ROCHE AG (CH) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012007375-A1 | PYRAZOLO [1, 5A] PYRIMIDINE AND THIENO [3, 2B] PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-19 | — | — | WO | disclosed |
| EP-1773843-A4 | SMALL MOLECULE THIENOPYRIMIDINE-BASED PROTEIN TYROSINE KINASE INHIBITORS | UNIV TEXAS (US) | 2009-06-03 | — | — | EP | disclosed |
| WO-2007056208-A2 | N-ARYLALKYL-THIENOPYRIMIDIN-4-AMINES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF | CYTOVIA, INC. (US) | 2007-05-18 | — | — | WO | disclosed |
| EP-1773843-A1 | SMALL MOLECULE THIENOPYRIMIDINE-BASED PROTEIN TYROSINE KINASE INHIBITORS | The Board of Regents of The University of Texas System (US) | 2007-04-18 | — | — | EP | disclosed |
| WO-2006014404-A1 | SMALL MOLECULE THIENOPYRIMIDINE-BASED PROTEIN TYROSINE KINASE INHIBITORS | BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2006-02-09 | — | — | WO | disclosed |
| EP-1409491-A2 | THIENOPYRIMIDINE-BASED INHIBITORS OF THE SRC FAMILY | Board of Regents, The University of Texas System (US) | 2004-04-21 | — | — | EP | disclosed |
| WO-2002057271-A2 | THIENOPYRIMIDINE-BASED INHIBITORS OF THE SRC FAMILY | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2002-07-25 | — | — | WO | disclosed |