Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 5/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30753216 | 0.75 | TSHR (0.39) | KMT2APOLBNPSR1CYP1A2NPC1 | |
| SCHEMBL29070876 | 0.75 | KDM4E (0.47) | KMT2APOLBNPSR1CYP1A2CYP2C9 | |
| SCHEMBL30753229 | 0.72 | HTT (0.39) | KMT2APOLBNPSR1CYP1A2NPC1 | |
| SCHEMBL31636767 | 0.72 | ERCC1 (0.41) | KMT2ANPSR1CYP1A2MEN1KDM4E | |
| SCHEMBL30984297 | 0.72 | KDM4E (0.39) | KMT2ANPSR1CYP1A2TDP1NPC1 | |
| SCHEMBL30984212 | 0.72 | KDM4E (0.39) | KMT2ANPSR1CYP1A2TDP1NPC1 | |
| SCHEMBL370324 | 0.71 | L3MBTL1 (0.43) | KMT2ANPSR1CYP1A2NPC1MEN1 | |
| SCHEMBL14074693 | 0.71 | ADORA2A (0.56) | KMT2ANPSR1CYP1A2NPC1RAB9A | |
| SCHEMBL370633 | 0.71 | DYRK1A (0.53) | DYRK1APOLBCYP2C19TDP1NPC1 | |
| SCHEMBL1493959 | 0.69 | KMT2A (0.39) | KMT2ANPSR1CYP1A2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2470538-A1 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | Array Biopharma, Inc. (US) | 2012-07-04 | — | — | EP | disclosed |
| WO-2011025940-A1 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2011-03-03 | — | — | WO | disclosed |