Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR2 | P50052 | 4/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
| ▸ | BTK | Q06187 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1449838 | 0.85 | BTK (0.34) | RETBTKJAK2JAK1JAK3 | |
| SCHEMBL11913112 | 0.79 | CYP3A4 (0.40) | RETBTKJAK1 | |
| SCHEMBL3705463 | 0.73 | SMYD3 (0.30) | — | |
| SCHEMBL1450060 | 0.70 | GPR119 (0.39) | RETBTK | |
| SCHEMBL1449671 | 0.69 | RET (0.36) | RET | |
| SCHEMBL11901108 | 0.68 | GPR119 (0.39) | RETJAK2JAK1 | |
| SCHEMBL11913108 | 0.68 | GPR119 (0.59) | — | |
| SCHEMBL1449881 | 0.67 | RET (0.35) | RET | |
| SCHEMBL11913121 | 0.67 | GPR119 (0.49) | — | |
| SCHEMBL1449901 | 0.66 | RET (0.41) | RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2144902-B1 | [6,6]AND [6,7]-BICYCLIC GPR119 G PROTEIN-COUPLED RECEPTOR AGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2012-05-16 | — | — | EP | disclosed |