Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KDM1A | O60341 | 5/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.44 |
| ▸ | HTR2A | P28223 | 3/20 | 0.44 |
| ▸ | HTR2C | P28335 | 3/20 | 0.44 |
| ▸ | HTR2B | P41595 | 3/20 | 0.44 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.43 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.41 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.41 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.41 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27870205 | 0.72 | SRD5A1 (0.37) | MAPK1SMN1; SMN2SRD5A1 | |
| SCHEMBL21845244 | 0.69 | KDM1A (0.50) | MAPK1SMN1; SMN2KDM1ASIGMAR1GRIN2D | |
| SCHEMBL13262553 | 0.69 | GRIN2D (0.50) | MAPK1SMN1; SMN2KDM1ASIGMAR1GRIN2D | |
| SCHEMBL10092817 | 0.68 | MCHR2 (0.50) | MAPK1SMN1; SMN2KDM1ASIGMAR1HTR2A | |
| SCHEMBL2743258 | 0.66 | SIGMAR1 (0.67) | SIGMAR1HTR2AHTR2CHTR2B | |
| SCHEMBL12021583 | 0.65 | MAOA (0.47) | MAPK1SMN1; SMN2KDM1ASIGMAR1HTR2A | |
| SCHEMBL14193182 | 0.65 | HTR2A (0.66) | MAPK1SMN1; SMN2SIGMAR1HTR2AHTR2C | |
| SCHEMBL1207260 | 0.65 | SRD5A1 (0.45) | MAPK1SMN1; SMN2KDM1ASIGMAR1HTR2A | |
| SCHEMBL12389036 | 0.65 | KDM1A (0.44) | KDM1AGRIN1GRIN2AMAOB | |
| SCHEMBL19031400 | 0.64 | KDM1A (0.70) | KDM1AMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2207549-A1 | MODULATORS OF MUSCARINIC RECEPTORS | Vertex Pharmceuticals Incorporated (US) | 2010-07-21 | — | — | EP | disclosed |
| WO-2009045519-A1 | MODULATORS OF MUSCARINIC RECEPTORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-04-09 | — | — | WO | disclosed |