Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Tetrahydrocortisone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | G6PD | P11413 | 4/20 | 0.73 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.72 |
| ▸ | GABRA1 | P14867 | 5/20 | 0.54 |
| ▸ | GABRB2 | P47870 | 5/20 | 0.54 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.54 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.54 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | GLA | P06280 | 1/20 | 0.54 |
| ▸ | GABRP | O00591 | 2/20 | 0.52 |
| ▸ | GABRD | O14764 | 2/20 | 0.52 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.52 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.52 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.52 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.52 |
| ▸ | GABRE | P78334 | 2/20 | 0.52 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetrahydrocortisone SCHEMBL16833654 | 0.97 | G6PD (0.72) | G6PDCYP3A4GABRA1GABRB2GABRG2 | |
| Tetrahydrocortisone SCHEMBL7857249 | 0.97 | G6PD (0.74) | G6PDCYP3A4GABRA1GABRB2GABRG2 | |
| Tetrahydrocortisone SCHEMBL14843416 | 0.96 | G6PD (0.76) | G6PDCYP3A4GABRA1GABRB2GABRG2 | |
| Tetrahydrocortisone SCHEMBL5610354 | 0.96 | G6PD (0.79) | G6PDCYP3A4GABRA1GABRB2GABRG2 | |
| Tetrahydrocortisone SCHEMBL4111245 | 0.96 | G6PD (0.79) | G6PDCYP3A4GABRA1GABRB2GABRG2 | |
| Tetrahydrocortisone SCHEMBL1332665 | 0.96 | G6PD (0.79) | G6PDCYP3A4GABRA1GABRB2GABRG2 | |
| Tetrahydrocortisone SCHEMBL193711 | 0.96 | G6PD (0.79) | G6PDCYP3A4GABRA1GABRB2GABRG2 | |
| Tetrahydrocortisone SCHEMBL1184192 | 0.96 | G6PD (0.79) | G6PDCYP3A4GABRA1GABRB2GABRG2 | |
| Tetrahydrocortisone SCHEMBL1184193 | 0.96 | G6PD (0.79) | G6PDCYP3A4GABRA1GABRB2GABRG2 | |
| Tetrahydrocortisone SCHEMBL10526995 | 0.95 | G6PD (0.69) | G6PDCYP3A4GABRA1GABRB2GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 367 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110171866-A | A kind of Congo red and crystal violet organic pollutant processing method | 河南大学 | 2019-08-27 | — | — | CN | claimed |
| CN-105263462-B | Gelatin-free enteric soft capsules | 帕西恩软胶公司 | 2019-11-22 | — | — | CN | disclosed |
| CN-110412159-A | The method of alkyl mercury in sulfhydryl modified silica gel, preparation method and application, and detection water | GUANGDIAN METERING DETECTION NANNING CO LTD | 2019-11-05 | — | — | CN | disclosed |
| CN-110392528-A | The dangerous disinfectant and fungicide of sucking is reduced by heavy polymer | 埃科莱布美国股份有限公司 | 2019-10-29 | — | — | CN | disclosed |
| CN-110392570-A | With husky trastuzumab lattice dimension for the triple negative breast cancer of health and RAD51 inhibitor for treating expression TROP-2 | 免疫医疗公司 | 2019-10-29 | — | — | CN | disclosed |
| CN-110382679-A | Interaction mechanism of urea/solid acid under storage conditions and storage stable solid composition comprising urea and acid | 埃科莱布美国股份有限公司 | 2019-10-25 | — | — | CN | disclosed |
| CN-110317337-A | Over-branched polyamidoamine, preparation method and its application in terms of heavy mental treatment | 威海晨源分子新材料有限公司 | 2019-10-11 | — | — | CN | disclosed |
| CN-110256256-A | A kind of MovTwo-dimentional polyoxometallate crystalline material constructed and preparation method thereof | 河南大学 | 2019-09-20 | — | — | CN | disclosed |
| CN-110256256-A | A kind of MovTwo-dimentional polyoxometallate crystalline material constructed and preparation method thereof | 河南大学 | 2019-09-20 | — | — | CN | disclosed |
| CN-106552666-B | A kind of catalyst for preparing olefin by catalytic cracking and its preparation method and application | 中国石油化工股份有限公司 | 2019-09-10 | — | — | CN | disclosed |
| CN-1087671-A | The liquid detergent composition that contains proteolytic enzyme and some alpha beta-aminoalkylboronic acid and its ester | PROCTER & GAMBLE (US) | 1994-06-08 | — | — | CN | disclosed |
| CN-1085941-A | The liquid washing agent that contains peptide trifluoromethyl ketone | PROCTER & GAMBLE (US) | 1994-04-27 | — | — | CN | disclosed |
| CN-1078994-A | Cleaning compositions containing glycerol amides | PROCTER & GAMBLE (US) | 1993-12-01 | — | — | CN | disclosed |
| CN-1070223-A | The purging compound that contains polyhydroxy fatty acid amide surfactant and clay softening system | PROCTER & GAMBLE (US) | 1993-03-24 | — | — | CN | disclosed |
| CN-1067264-A | The liquid detergents with aromatic borate of arrestin lytic enzyme | PROCTER & GAMBLE (US) | 1992-12-23 | — | — | CN | disclosed |
| CN-1063123-A | Contain the polyhydroxy fatty acid amide in the liquid detergent composition of whitening agent | PROCTER & GAMBLE (US) | 1992-07-29 | — | — | CN | disclosed |
| CN-1061618-A | Polyhydroxy fatty acid amide in zeolite/composite washing of laminar silicate | PROCTER & GAMBLE (US) | 1992-06-03 | — | — | CN | disclosed |
| CN-1061241-A | The promoted method of phase transition that is used for glucamide detergents | PROCTER & GAMBLE (US) | 1992-05-20 | — | — | CN | disclosed |
| CN-1061036-A | The detergent composition that contains anion surfactant, polyhydroxy fatty acid amide and magnesium | PROCTER & GABMLE CO (US) | 1992-05-13 | — | — | CN | disclosed |
| CN-1038411-A | The silver catalyst that is used for ethylene oxide production | CHINA PETRO CHEMICAL CO (CN) | 1990-01-03 | — | — | CN | disclosed |