SCHEMBL3706595

SCHEMBL3706595

COc1ccc2c(c1)C(O)n1c-2cc2c(-c3ccccc3)cc(C(=O)NS(=O)(=O)N(C)C)cc21

nearest known ligand 0.40

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
NR1I2 O75469 5/20 0.40
CYP3A4 P08684 3/20 0.40
CYP2C9 P11712 1/20 0.40
CYP2C19 P33261 1/20 0.40
KCNH2 Q12809 4/20 0.39
SCN5A Q14524 3/20 0.39
SCN9A Q15858 3/20 0.37
PTGER4 P35408 2/20 0.35
KAT6A Q92794 1/20 0.34
CHRM3 P20309 1/20 0.34
AURKA O14965 1/20 0.33
TPX2 Q9ULW0 1/20 0.33
HDAC8 Q9BY41 1/20 0.33
HPGD P15428 1/20 0.33
TSHR P16473 1/20 0.33
HSP90AA1 P07900 1/20 0.33
HSP90AB1 P08238 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3857114 0.88 NR1I2 (0.40) NR1I2CYP3A4CYP2C9CYP2C19KCNH2
SCHEMBL3706594 0.84 KCNH2 (0.48) NR1I2CYP3A4CYP2C9CYP2C19KCNH2
SCHEMBL2637667 0.84 NR1I2 (0.47) NR1I2CYP3A4CYP2C9CYP2C19KCNH2
SCHEMBL50643 0.74 NR1I2 (0.46) NR1I2CYP3A4CYP2C9CYP2C19KCNH2
SCHEMBL2637665 0.73 NR1I2 (0.64) NR1I2CYP3A4CYP2C9CYP2C19KCNH2
SCHEMBL3842628 0.71 ALDH1A1 (0.37) SCN9A
SCHEMBL5927486 0.69 SCN9A (0.40) NR1I2CYP3A4CYP2C9CYP2C19KCNH2
SCHEMBL5927646 0.69 NR1I2 (0.41) NR1I2CYP3A4CYP2C9CYP2C19KCNH2
SCHEMBL3907053 0.69 MAPK8 (0.41) CYP3A4CYP2C9CYP2C19HPGD
SCHEMBL5927627 0.68 KDM4E (0.40) CYP3A4CYP2C9CYP2C19HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2215095-A1 CYCLOPROPYL FUSED INDOLOBENZAZEPINE DERIVATIVES FOR THE TREATMENT OF HEPATITIS C Bristol-Myers Squibb Company (US) 2010-08-11 EP disclosed
EP-2209784-A1 COMPOUNDS FOR THE TREATMENT OF HEPATITIS C Bristol-Myers Squibb Company (US) 2010-07-28 EP disclosed
EP-2209789-A1 CYCLOPROPYL FUSED INDOLOBENZAZEPINE HCV NS5B INHIBITORS Bristol-Myers Squibb Company (US) 2010-07-28 EP disclosed
EP-2121697-A1 COMPOUNDS FOR THE TREATMENT OF HEPATITIS C Bristol-Myers Squibb Company (US) 2009-11-25 EP disclosed
EP-2121696-A1 COMPOUNDS FOR THE TREATMENT OF HEPATITIS C Brystol-Myers Squibb Company (US) 2009-11-25 EP disclosed
EP-2118109-A1 COMPOUNDS FOR THE TREATMENT OF HEPATITIS C Bristol-Myers Squibb Company (US) 2009-11-18 EP disclosed
EP-2118108-A1 COMPOUNDS FOR THE TREATMENT OF HEPATITIS C Bristol-Myers Squibb Company (US) 2009-11-18 EP disclosed
EP-2114947-A1 INDOLOBENZAZEPINE DERIVATIVES FOR THE TREATMENT OF HEPATITIS C Brystol-Myers Squibb Company (US) 2009-11-11 EP disclosed
EP-2099804-A1 COMPOUNDS FOR THE TREATMENT OF HEPATITIS C Brystol-Myers Squibb Company (US) 2009-09-16 EP disclosed
WO-2009067481-A1 COMPOUNDS FOR THE TREATMENT OF HEPATITIS C BRISTOL-MYERS SQUIBB COMPANY (US) 2009-05-28 WO disclosed
WO-2008112863-A1 COMPOUNDS FOR THE TREATMENT OF HEPATITIS C BRISTOL-MYERS SQUIBB COMPANY (US) 2008-09-18 WO disclosed
WO-2008112841-A1 COMPOUNDS FOR THE TREATMENT OF HEPATITIS C BRISTOL-MYERS SQUIBB COMPANY (US) 2008-09-18 WO disclosed
WO-2008112848-A1 COMPOUNDS FOR THE TREATMENT OF HEPATITIS C BRISTOL-MYERS SQUIBB COMPANY (US) 2008-09-18 WO disclosed
WO-2008112473-A1 COMPOUNDS FOR THE TREATMENT OF HEPATITIS C BRISTOL-MYERS SQUIBB COMPANY (US) 2008-09-18 WO disclosed
WO-2008097796-A1 INDOLOBENZAZEPINE DERIVATIVES FOR THE TREATMENT OF HEPATITIS C BRISTOL-MYERS SQUIBB COMPANY (US) 2008-08-14 WO disclosed
WO-2008089027-A1 COMPOUNDS FOR THE TREATMENT OF HEPATITIS C BRISTOL-MYERS SQUIBB COMPANY (US) 2008-07-24 WO disclosed
WO-2007140200-A2 CYCLOPROPYL FUSED INDOLOBENZAZEPINE HCV NS5B INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2007-12-06 WO disclosed
WO-2007140109-A1 CYCLOPROPYL FUSED INDOLOBENZAZEPINE HCV NS5B INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2007-12-06 WO disclosed
WO-2007136982-A1 CYCLOPROPYL FUSED INDOLOBENZAZEPINE HCV NS5B INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2007-11-29 WO disclosed
WO-2007033175-A1 INDOLOBENZAZEPINE HCV NS5B INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2007-03-22 WO disclosed