Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | KDM4A | O75164 | 1/20 | 0.36 |
| ▸ | KDM4B | O94953 | 1/20 | 0.36 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.36 |
| ▸ | TTR | P02766 | 4/20 | 0.36 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.36 |
| ▸ | PTPRC | P08575 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.33 |
| ▸ | RXRB | P28702 | 1/20 | 0.33 |
| ▸ | RXRG | P48443 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL772512 | 0.75 | ALDH1A1 (0.37) | ALDH1A1TTRPTPRCPOLBKMT2A | |
| SCHEMBL5312887 | 0.71 | ALDH1A1 (0.38) | ALDH1A1KDM4AKDM4BKDM4DKDM4C | |
| SCHEMBL10988314 | 0.64 | MEN1 (0.59) | ALDH1A1KDM4AKDM4BKDM4DKDM4C | |
| SCHEMBL29279320 | 0.63 | PTPN1 (0.58) | ALDH1A1KDM4AKDM4BKDM4DKDM4C | |
| SCHEMBL10900757 | 0.62 | GRIN2D (0.53) | ALDH1A1KDM4AKDM4BKDM4DKDM4C | |
| SCHEMBL30184435 | 0.60 | HTR2B (0.61) | ALDH1A1TTRPTPRCPOLBKMT2A | |
| SCHEMBL7596515 | 0.60 | XDH (0.44) | KDM4AKDM4BKDM4DKDM4CP2RY14 | |
| SCHEMBL9301722 | 0.60 | P2RY14 (0.63) | ALDH1A1KDM4AKDM4BKDM4DKDM4C | |
| SCHEMBL10578274 | 0.60 | XDH (0.44) | ALDH1A1KDM4AKDM4BKDM4DKDM4C | |
| SCHEMBL27972376 | 0.60 | ALDH1A1 (0.44) | ALDH1A1TTRPOLBKMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114947-A1 | INDOLOBENZAZEPINE DERIVATIVES FOR THE TREATMENT OF HEPATITIS C | Brystol-Myers Squibb Company (US) | 2009-11-11 | — | — | EP | disclosed |
| EP-2099804-A1 | COMPOUNDS FOR THE TREATMENT OF HEPATITIS C | Brystol-Myers Squibb Company (US) | 2009-09-16 | — | — | EP | disclosed |
| WO-2008097796-A1 | INDOLOBENZAZEPINE DERIVATIVES FOR THE TREATMENT OF HEPATITIS C | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-08-14 | — | — | WO | disclosed |
| WO-2008089027-A1 | COMPOUNDS FOR THE TREATMENT OF HEPATITIS C | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-07-24 | — | — | WO | disclosed |
| WO-2007033032-A1 | CYCLOPROPYL FUSED INDOLOBENZAZEPINE HCV NS5B INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-03-22 | — | — | WO | disclosed |
| WO-2007033175-A1 | INDOLOBENZAZEPINE HCV NS5B INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-03-22 | — | — | WO | disclosed |