SCHEMBL3706726

SCHEMBL3706726

COc1cccc2c1C(O)CC1(CCN(Cc3ccccc3)CC1)O2

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC3 O15379 2/20 0.52
HDAC4 P56524 2/20 0.52
HDAC1 Q13547 2/20 0.52
HDAC7 Q8WUI4 2/20 0.52
HDAC2 Q92769 2/20 0.52
HDAC10 Q969S8 2/20 0.52
HDAC11 Q96DB2 2/20 0.52
HDAC8 Q9BY41 2/20 0.52
HDAC6 Q9UBN7 2/20 0.52
HDAC9 Q9UKV0 2/20 0.52
HDAC5 Q9UQL6 2/20 0.52
SIGMAR1 Q99720 4/20 0.50
MEN1 O00255 2/20 0.46
KMT2A Q03164 2/20 0.46
POLB P06746 1/20 0.46
ACHE P22303 4/20 0.45
BACE1 P56817 4/20 0.45
BCHE P06276 3/20 0.45
SLC6A12 P48065 1/20 0.43
HTR1A P08908 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3709881 0.84 SIGMAR1 (0.54) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL16496003 0.82 IDO1 (0.49) MEN1KMT2A
SCHEMBL1175163 0.76 HDAC3 (0.66) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL16495736 0.73 IDO1 (0.47) MEN1KMT2A
SCHEMBL2128964 0.73 HDAC3 (0.79) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL2128960 0.73 HDAC3 (0.79) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL16496610 0.69 KMT2A (0.47) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL11390168 0.68 SIGMAR1 (0.45) SIGMAR1MEN1KMT2AHTR1AADRA1D
SCHEMBL16495742 0.68 TRPM8 (0.47)
SCHEMBL12481588 0.68 HTT (0.51) KMT2APOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2398809-A1 NOVEL SPIRO COMPOUNDS USEFUL AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE Merck Canada Inc. (CA) 2011-12-28 EP disclosed
WO-2010094120-A1 NOVEL SPIRO COMPOUNDS USEFUL AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE MERCK FROSST CANADA LTD. (CA) 2010-08-26 WO disclosed