Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 12/20 | 0.56 |
| ▸ | PIK3CA | P42336 | 11/20 | 0.56 |
| ▸ | PI4KA | P42356 | 10/20 | 0.56 |
| ▸ | PI4KB | Q9UBF8 | 10/20 | 0.56 |
| ▸ | PIK3CD | O00329 | 8/20 | 0.56 |
| ▸ | PIK3CB | P42338 | 7/20 | 0.56 |
| ▸ | PIP5K1C | O60331 | 5/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3713839 | 0.90 | PIK3CA (0.54) | PIK3CGPIK3CAPI4KAPI4KBPIK3CD | |
| SCHEMBL12855289 | 0.82 | RAB9A (0.60) | CYP2D6CYP2C9CYP2C19KDM4ENPC1 | |
| SCHEMBL3716661 | 0.80 | PIK3CG (0.71) | PIK3CGPIK3CA | |
| SCHEMBL3707973 | 0.79 | PI4KA (0.70) | PIK3CGPIK3CAPI4KAPI4KBPIK3CD | |
| SCHEMBL3708442 | 0.78 | PIK3CA (0.65) | PIK3CGPIK3CAPI4KAPI4KBPIK3CD | |
| SCHEMBL3711132 | 0.78 | PIK3CA (0.53) | PIK3CGPIK3CAPI4KAPI4KBPIK3CD | |
| SCHEMBL22470617 | 0.76 | PIK3CA (0.59) | PIK3CGPIK3CAPI4KAPI4KBPIK3CD | |
| SCHEMBL22470569 | 0.75 | PI4KA (0.60) | PIK3CGPIK3CAPI4KAPI4KBPIK3CD | |
| SCHEMBL29714022 | 0.75 | PI4KA (0.60) | PIK3CGPIK3CAPI4KAPI4KBPIK3CD | |
| SCHEMBL12543471 | 0.74 | PI4KA (0.66) | PIK3CGPIK3CAPI4KAPI4KBPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100144-A1 | FUSED BICYCLIC COMPOUNDS AS INHIBITORS FOR PI3 KINASE | MERCK SERONO S.A. (CH) | 2010-09-10 | — | — | WO | disclosed |
| WO-2010100144-A1 | FUSED BICYCLIC COMPOUNDS AS INHIBITORS FOR PI3 KINASE | MERCK SERONO S.A. (CH) | 2010-09-10 | — | — | WO | disclosed |