Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KA | P42356 | 18/20 | 0.70 |
| ▸ | PI4KB | Q9UBF8 | 18/20 | 0.70 |
| ▸ | PIK3CA | P42336 | 17/20 | 0.70 |
| ▸ | PIK3CD | O00329 | 16/20 | 0.70 |
| ▸ | PIK3CB | P42338 | 15/20 | 0.70 |
| ▸ | PIK3CG | P48736 | 13/20 | 0.70 |
| ▸ | PIP5K1C | O60331 | 6/20 | 0.58 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.49 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3710857 | 0.82 | PI4KA (1.00) | PI4KAPI4KBPIK3CAPIK3CDPIK3CB | |
| SCHEMBL3708442 | 0.81 | PIK3CA (0.65) | PI4KAPI4KBPIK3CAPIK3CDPIK3CB | |
| SCHEMBL3706887 | 0.79 | PIK3CG (0.56) | PI4KAPI4KBPIK3CAPIK3CDPIK3CB | |
| SCHEMBL3713839 | 0.78 | PIK3CA (0.54) | PI4KAPI4KBPIK3CAPIK3CDPIK3CB | |
| SCHEMBL12543471 | 0.78 | PI4KA (0.66) | PI4KAPI4KBPIK3CAPIK3CDPIK3CB | |
| SCHEMBL3717838 | 0.77 | PI4KA (0.76) | PI4KAPI4KBPIK3CAPIK3CDPIK3CB | |
| SCHEMBL3711132 | 0.77 | PIK3CA (0.53) | PI4KAPI4KBPIK3CAPIK3CDPIK3CB | |
| SCHEMBL25303323 | 0.75 | PI4KA (0.72) | PI4KAPI4KBPIK3CAPIK3CDPIK3CB | |
| SCHEMBL29646253 | 0.75 | PIK3CA (0.82) | PI4KAPI4KBPIK3CAPIK3CDPIK3CB | |
| SCHEMBL5532470 | 0.75 | PIK3CA (0.82) | PI4KAPI4KBPIK3CAPIK3CDPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100144-A1 | FUSED BICYCLIC COMPOUNDS AS INHIBITORS FOR PI3 KINASE | MERCK SERONO S.A. (CH) | 2010-09-10 | — | — | WO | disclosed |
| WO-2010100144-A1 | FUSED BICYCLIC COMPOUNDS AS INHIBITORS FOR PI3 KINASE | MERCK SERONO S.A. (CH) | 2010-09-10 | — | — | WO | disclosed |