Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | BCHE | P06276 | 2/20 | 0.53 |
| ▸ | ACHE | P22303 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.51 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6313152 | 1.00 | L3MBTL1 (0.61) | L3MBTL1HSD17B10KDM4EALDH1A1HPGD | |
| SCHEMBL8242593 | 0.93 | L3MBTL1 (0.58) | L3MBTL1HSD17B10KDM4EALDH1A1HPGD | |
| SCHEMBL2251586 | 0.93 | L3MBTL1 (0.58) | L3MBTL1HSD17B10KDM4EALDH1A1HPGD | |
| SCHEMBL27584197 | 0.93 | L3MBTL1 (0.65) | L3MBTL1HSD17B10KDM4EALDH1A1HPGD | |
| SCHEMBL27630597 | 0.92 | L3MBTL1 (0.52) | L3MBTL1HSD17B10KDM4EALDH1A1HPGD | |
| SCHEMBL16509378 | 0.89 | L3MBTL1 (0.61) | L3MBTL1HSD17B10KDM4EALDH1A1HPGD | |
| SCHEMBL11631569 | 0.88 | L3MBTL1 (0.67) | L3MBTL1HSD17B10KDM4EALDH1A1HPGD | |
| SCHEMBL11631574 | 0.88 | L3MBTL1 (0.67) | L3MBTL1HSD17B10KDM4EALDH1A1HPGD | |
| SCHEMBL10829643 | 0.88 | L3MBTL1 (0.50) | L3MBTL1HSD17B10KDM4EALDH1A1HPGD | |
| SCHEMBL10829650 | 0.88 | L3MBTL1 (0.50) | L3MBTL1HSD17B10KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100376546-C | Diethyl 4(4-oxobutyl) benzoyl-L-glutamate and its preparation and use | UNIV ZHEJIANG POLYTECHNIC (CN) | 2008-03-26 | — | — | CN | claimed |
| CN-1321975-C | Diethyl 4[(4-oxo-3-bromo) butyl] benzoyl-L-glutamate and preparation and use | UNIV ZHEJIANG POLYTECHNIC (CN) | 2007-06-20 | — | — | CN | claimed |
| CN-1821220-A | Diethyl 4[(4-oxo-3-bromo) butyl] benzoyl-L-glutamate and preparation and use | UNIV ZHEJIANG POLYTECHNIC (CN) | 2006-08-23 | — | — | CN | claimed |
| CN-1821219-A | Diethyl 4(4-oxobutyl) benzoyl-L-glutamate and its preparation and use | UNIV ZHEJIANG POLYTECHNIC (CN) | 2006-08-23 | — | — | CN | claimed |
| US-20110306671-A1 | AMIDE DERIVATIVES OF ETHACRYNIC ACID | The Regents of the The University of California (US) | 2011-12-15 | — | — | US | disclosed |
| WO-2010077310-A2 | AMIDE DERIVATIVES OF ETHACRYNIC ACID | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-07-08 | — | — | WO | disclosed |
| CN-100379729-C | Nitro compounds and their application in preparation of pemetrexed | HAINAN TIANYUAN KANGZE PHARMAC (CN) | 2008-04-09 | — | — | CN | disclosed |
| CN-1321975-C | Diethyl 4[(4-oxo-3-bromo) butyl] benzoyl-L-glutamate and preparation and use | UNIV ZHEJIANG POLYTECHNIC (CN) | 2007-06-20 | — | — | CN | disclosed |
| CN-1827604-A | Nitro compounds and their application in preparation of pemetrexed | HENAN TIANYUAN KANGZE PHARMACE (CN) | 2006-09-06 | — | — | CN | disclosed |
| CN-1821220-A | Diethyl 4[(4-oxo-3-bromo) butyl] benzoyl-L-glutamate and preparation and use | UNIV ZHEJIANG POLYTECHNIC (CN) | 2006-08-23 | — | — | CN | disclosed |
| CN-1049215-C | Process for preparing benzoquinazoline thymidylate synthase inhibitors | WELLOCOME FOUNDATION LTD (GB) | 2000-02-09 | — | — | CN | disclosed |
| CN-1040209-C | Method for the production of folic acid | HOFFMANN LA ROCHE (CH) | 1998-10-14 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110306671-A1 | AMIDE DERIVATIVES OF ETHACRYNIC ACID | EPX, TNF, NFKBIA | L3MBTL1 1377/4885HSD17B10 1502/4885KDM4E 4196/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.