SCHEMBL3707716

SCHEMBL3707716

O=C(Nc1cc(-c2ccncc2)c[nH]c1=O)[C@H](Cc1ccccc1)N(c1ccccn1)C1CC1

nearest known ligand 0.61

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
GPR142 Q7Z601 20/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3710190 0.82 GPR142 (0.60) GPR142
SCHEMBL3718144 0.81 GPR142 (0.53) GPR142
SCHEMBL2686213 0.77 GPR142 (1.00) GPR142
SCHEMBL2686207 0.77 GPR142 (1.00) GPR142
SCHEMBL2684485 0.75 GPR142 (1.00) GPR142
SCHEMBL2684482 0.75 GPR142 (1.00) GPR142
SCHEMBL3714046 0.74 GPR142 (0.62) GPR142
SCHEMBL3713017 0.73 GPR142 (0.51) GPR142
SCHEMBL10062811 0.71 ITK (0.68) GPR142
SCHEMBL10062843 0.71 ITK (0.75) GPR142

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010093849-A2 PHENYLALANINE AMIDE DERIVATIVES USEFUL FOR TREATING INSULIN-RELATED DISEASES AND CONDITIONS AMGEN INC. (US) 2010-08-19 WO disclosed