Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.30 |
| ▸ | NPC1 | O15118 | 2/20 | 0.30 |
| ▸ | POLB | P06746 | 2/20 | 0.30 |
| ▸ | RAB9A | P51151 | 2/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | TYR | P14679 | 1/20 | 0.30 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.30 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.30 |
| ▸ | RELA | Q04206 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | GRM8 | O00222 | 1/20 | 0.30 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL369284 | 0.89 | TRPV4 (0.38) | TRPV4MEN1NPC1POLBRAB9A | |
| SCHEMBL12482588 | 0.82 | TRPV4 (0.39) | TRPV4MEN1NPC1POLBRAB9A | |
| SCHEMBL15166609 | 0.80 | MEN1 (0.39) | TRPV4MEN1NPC1POLBRAB9A | |
| SCHEMBL2534001 | 0.79 | MEN1 (0.42) | TRPV4MEN1NPC1POLBRAB9A | |
| SCHEMBL370423 | 0.78 | NPC1 (0.41) | TRPV4MEN1NPC1POLBRAB9A | |
| SCHEMBL12482295 | 0.76 | MEN1 (0.36) | TRPV4MEN1NPC1POLBRAB9A | |
| SCHEMBL12482053 | 0.76 | PDE10A (0.39) | TRPV4MEN1NPC1POLBRAB9A | |
| SCHEMBL370580 | 0.75 | NPC1 (0.36) | TRPV4MEN1NPC1POLBRAB9A | |
| SCHEMBL2538671 | 0.74 | NPC1 (0.44) | TRPV4MEN1NPC1POLBRAB9A | |
| SCHEMBL370330 | 0.72 | WNT3A (0.37) | MEN1NPC1RAB9AKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2595986-A2 | NOVEL 2-AMINO-4-PYRAZOLYL-THIAZOLE DERIVATIVES AND THEIR USE AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Addex Pharma SA (CH) | 2013-05-29 | — | — | EP | disclosed |
| WO-2012009009-A2 | NOVEL 2-AMINO-4-PYRAZOLYL-THIAZOLE DERIVATIVES AND THEIR USE AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ADDEX PHARMA S.A. (CH) | 2012-01-19 | — | — | WO | disclosed |