Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 18/20 | 0.50 |
| ▸ | PI4KA | P42356 | 16/20 | 0.50 |
| ▸ | PI4KB | Q9UBF8 | 16/20 | 0.50 |
| ▸ | PIK3CD | O00329 | 15/20 | 0.50 |
| ▸ | PIK3CG | P48736 | 14/20 | 0.50 |
| ▸ | PIK3CB | P42338 | 13/20 | 0.50 |
| ▸ | PIP5K1C | O60331 | 5/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.43 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3707953 | 0.89 | PIK3CA (0.53) | PIK3CAPI4KAPI4KBPIK3CDPIK3CG | |
| SCHEMBL3711629 | 0.84 | NPC1 (0.67) | PIK3CAPI4KAPI4KBPIK3CDPIK3CG | |
| SCHEMBL25834482 | 0.72 | MAPT (0.63) | PIK3CAPI4KAPI4KBPIK3CDPIK3CG | |
| SCHEMBL25303323 | 0.72 | PI4KA (0.72) | PIK3CAPI4KAPI4KBPIK3CDPIK3CG | |
| SCHEMBL12543471 | 0.72 | PI4KA (0.66) | PIK3CAPI4KAPI4KBPIK3CDPIK3CG | |
| SCHEMBL5532470 | 0.71 | PIK3CA (0.82) | PIK3CAPI4KAPI4KBPIK3CDPIK3CG | |
| SCHEMBL29646253 | 0.71 | PIK3CA (0.82) | PIK3CAPI4KAPI4KBPIK3CDPIK3CG | |
| SCHEMBL3708484 | 0.71 | SCN4A (0.62) | PIK3CAPI4KAPI4KBPIK3CDPIK3CG | |
| SCHEMBL31114781 | 0.71 | NPC1 (0.82) | PIK3CAPI4KAPI4KBPIK3CDPIK3CG | |
| SCHEMBL25259671 | 0.71 | NPC1 (0.82) | PIK3CAPI4KAPI4KBPIK3CDPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100144-A1 | FUSED BICYCLIC COMPOUNDS AS INHIBITORS FOR PI3 KINASE | MERCK SERONO S.A. (CH) | 2010-09-10 | — | — | WO | disclosed |