Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KA | P42356 | 16/20 | 0.76 |
| ▸ | PI4KB | Q9UBF8 | 16/20 | 0.76 |
| ▸ | PIK3CA | P42336 | 15/20 | 0.76 |
| ▸ | PIK3CD | O00329 | 14/20 | 0.76 |
| ▸ | PIK3CB | P42338 | 13/20 | 0.76 |
| ▸ | PIK3CG | P48736 | 12/20 | 0.76 |
| ▸ | PIP5K1C | O60331 | 6/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.48 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3710857 | 0.86 | PI4KA (1.00) | PI4KAPI4KBPIK3CAPIK3CDPIK3CB | |
| SCHEMBL13188896 | 0.86 | PI4KA (0.59) | PI4KAPI4KBPIK3CAPIK3CDPIK3CB | |
| SCHEMBL13188987 | 0.84 | PIK3CG (0.54) | PI4KAPI4KBPIK3CAPIK3CDPIK3CB | |
| SCHEMBL9722822 | 0.83 | ALDH1A1 (0.69) | PI4KAPI4KBPIK3CAPIK3CDPIK3CB | |
| SCHEMBL3719312 | 0.81 | PIK3CD (0.71) | PI4KAPI4KBPIK3CAPIK3CDPIK3CB | |
| SCHEMBL3718321 | 0.80 | PIK3CG (0.68) | PIK3CAPIK3CGHSD17B10 | |
| SCHEMBL3712762 | 0.80 | PIK3CG (0.59) | PI4KAPI4KBPIK3CAPIK3CDPIK3CB | |
| SCHEMBL3707973 | 0.77 | PI4KA (0.70) | PI4KAPI4KBPIK3CAPIK3CDPIK3CB | |
| SCHEMBL12543471 | 0.77 | PI4KA (0.66) | PI4KAPI4KBPIK3CAPIK3CDPIK3CB | |
| SCHEMBL3713842 | 0.75 | PI4KA (0.58) | PI4KAPI4KBPIK3CAPIK3CDPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100144-A1 | FUSED BICYCLIC COMPOUNDS AS INHIBITORS FOR PI3 KINASE | MERCK SERONO S.A. (CH) | 2010-09-10 | — | — | WO | disclosed |
| WO-2010100144-A1 | FUSED BICYCLIC COMPOUNDS AS INHIBITORS FOR PI3 KINASE | MERCK SERONO S.A. (CH) | 2010-09-10 | — | — | WO | disclosed |