Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 3/20 | 0.34 |
| ▸ | AKT1 | P31749 | 3/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | WNT1 | P04628 | 4/20 | 0.34 |
| ▸ | GSK3B | P49841 | 4/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 5/20 | 0.33 |
| ▸ | PPARA | Q07869 | 4/20 | 0.32 |
| ▸ | PPARD | Q03181 | 4/20 | 0.32 |
| ▸ | PPARG | P37231 | 2/20 | 0.32 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.32 |
| ▸ | CTSA | P10619 | 1/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2547011 | 1.00 | CDK2 (0.34) | CDK2AKT1SYKWNT1GSK3B | |
| SCHEMBL2547009 | 1.00 | CDK2 (0.34) | CDK2AKT1SYKWNT1GSK3B | |
| SCHEMBL1743812 | 0.87 | CDK2 (0.33) | CDK2AKT1WNT1GSK3BDYRK1A | |
| SCHEMBL12241690 | 0.87 | PDPK1 (0.34) | SYKWNT1GSK3BDYRK1A | |
| SCHEMBL2548525 | 0.86 | CDK2 (0.32) | CDK2AKT1SYKFFAR1PPARD | |
| SCHEMBL2545072 | 0.86 | AKT1 (0.38) | CDK2AKT1SYKWNT1GSK3B | |
| SCHEMBL2545074 | 0.86 | AKT1 (0.38) | CDK2AKT1SYKWNT1GSK3B | |
| SCHEMBL2548361 | 0.81 | FFAR2 (0.33) | FFAR1PPARGCTSACHRM5SLC6A3 | |
| SCHEMBL2548358 | 0.81 | FFAR2 (0.33) | FFAR1PPARGCTSACHRM5SLC6A3 | |
| SCHEMBL13286160 | 0.80 | AKT1 (0.37) | CDK2AKT1SYKWNT1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010083246-A1 | FLUOROISOQUINOLINE SUBSTITUTED THIAZOLE COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2010-07-22 | — | — | WO | disclosed |