SCHEMBL3708355

SCHEMBL3708355

C=Cc1cccc(OC(C)(C)Br)c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TP53 P04637 1/20 0.47
TDP1 Q9NUW8 1/20 0.47
CHRM5 P08912 1/20 0.38
RELA Q04206 1/20 0.37
ALDH1A1 P00352 2/20 0.37
TSHR P16473 1/20 0.37
CYP3A4 P08684 1/20 0.36
CYP2D6 P10635 1/20 0.36
MAPT P10636 1/20 0.36
CYP2C9 P11712 1/20 0.36
CYP2C19 P33261 1/20 0.36
NFE2L2 Q16236 2/20 0.35
FBP1 P09467 1/20 0.35
MAOA P21397 2/20 0.34
MAOB P27338 2/20 0.34
CYP19A1 P11511 1/20 0.34
NQO2 P16083 1/20 0.34
KDM4E B2RXH2 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
TRPA1 O75762 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30988604 0.87 TP53 (0.48) TP53TDP1CHRM5RELAALDH1A1
SCHEMBL408218 0.87 TP53 (0.48) TP53TDP1CHRM5RELAALDH1A1
SCHEMBL3709195 0.84 TDP1 (0.46) TP53TDP1CHRM5RELAALDH1A1
SCHEMBL1358728 0.82 TP53 (0.44) TP53TDP1CHRM5RELAALDH1A1
SCHEMBL1359683 0.81 TP53 (0.43) TP53TDP1CHRM5RELAALDH1A1
SCHEMBL5033484 0.81 TP53 (0.43) TP53TDP1CHRM5RELAALDH1A1
SCHEMBL17027024 0.80 LMNA (0.39) TP53ALDH1A1TSHRCYP3A4CYP2D6
SCHEMBL31381747 0.79 PIM1 (0.49) TP53TDP1ALDH1A1TSHR
SCHEMBL4293317 0.79 PIM1 (0.49) TP53TDP1ALDH1A1TSHR
SCHEMBL5888447 0.79 TDP1 (0.44) TP53TDP1CHRM5RELAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2393822-A1 PHOSPHINATE RUTHENIUM COMPLEXES IDENIX Pharmaceuticals, Inc. (US) 2011-12-14 EP disclosed
EP-2250174-A2 MACROCYCLIC SERINE PROTEASE INHIBITORS IDENIX Pharmaceuticals, Inc. (US) 2010-11-17 EP disclosed
WO-2010090976-A1 PHOSPHINATE RUTHENIUM COMPLEXES IDENIX PHARMACEUTICALS, INC. (US) 2010-08-12 WO disclosed
WO-2009099596-A2 MACROCYCLIC SERINE PROTEASE INHIBITORS IDENIX PHARAMACEUTICALS, INC. (US) 2009-08-13 WO disclosed