Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RNASEH1 | O60930 | 1/20 | 0.53 |
| ▸ | PDE5A | O76074 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.40 |
| ▸ | TUBB | P07437 | 1/20 | 0.40 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.40 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.40 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.40 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.40 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.40 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.40 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.40 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.40 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.40 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.40 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.40 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.40 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL403310 | 0.80 | PDE5A (0.62) | RNASEH1PDE5AMAPTTUBB4ATUBB | |
| SCHEMBL3055325 | 0.75 | MAPT (0.57) | RNASEH1PDE5AMAPTKMT2APOLB | |
| SCHEMBL401655 | 0.75 | PDE5A (0.74) | RNASEH1PDE5AMAPTKMT2AKDM4E | |
| SCHEMBL3063800 | 0.73 | RNASEH1 (0.52) | RNASEH1PDE5AMAPTKMT2AKDM4E | |
| SCHEMBL17888977 | 0.72 | RNASEH1 (0.55) | RNASEH1PDE5AMAPTKMT2AKDM4E | |
| SCHEMBL3064348 | 0.71 | SCD (0.60) | RNASEH1PDE5AMAPTKMT2AKDM4E | |
| SCHEMBL3651494 | 0.71 | RNASEH1 (0.48) | RNASEH1PDE5AMAPTTUBB4ATUBB | |
| SCHEMBL3063830 | 0.71 | MAPT (0.52) | RNASEH1MAPTKMT2APOLB | |
| SCHEMBL404377 | 0.70 | RNASEH1 (0.60) | RNASEH1PDE5AMAPTKMT2AKDM4E | |
| SCHEMBL3492915 | 0.70 | PDE5A (0.74) | RNASEH1PDE5AMAPTKMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010045374-A1 | 3-HYDROQUINAZOLIN-4-ONE DERIVATIVES FOR USE AS STEAROYL COA DESATURASE INHIBITORS | GILEAD PALO ALTO, INC. (US) | 2010-04-22 | — | — | WO | disclosed |