Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15675153 | 0.75 | KMT2A (0.50) | SMN1; SMN2ALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL9955074 | 0.75 | KMT2A (0.50) | SMN1; SMN2ALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL956652 | 0.72 | SMN1; SMN2 (0.34) | SMN1; SMN2ALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL15674698 | 0.70 | SMN1; SMN2 (0.40) | SMN1; SMN2ALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL10066477 | 0.70 | SMN1; SMN2 (0.40) | SMN1; SMN2ALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL15674404 | 0.69 | ALOX5 (0.36) | SMN1; SMN2ALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL9955946 | 0.69 | ALOX5 (0.36) | SMN1; SMN2ALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL10066610 | 0.67 | BCHE (0.33) | SMN1; SMN2ALDH1A1KMT2AMEN1CYP3A4 | |
| SCHEMBL1697681 | 0.65 | SMN1; SMN2 (0.58) | SMN1; SMN2ALDH1A1LMNAPOLBCYP1A2 | |
| SCHEMBL1697683 | 0.65 | SMN1; SMN2 (0.58) | SMN1; SMN2ALDH1A1LMNAPOLBCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2393807-A1 | CYCLIC INHIBITORS OF 11 -HYDROXYSTEROID DEHYDROGENASE 1 | Boehringer Ingelheim International GmbH (DE) | 2011-12-14 | — | — | EP | disclosed |
| WO-2010089303-A1 | CYCLIC INHIBITORS OF 11 β-HYDROXYSTEROID DEHYDROGENASE 1 | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-08-12 | — | — | WO | disclosed |