Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | DHODH | Q02127 | 2/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | XIAP | P98170 | 1/20 | 0.39 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.39 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3709739 | 0.90 | MEN1 (0.41) | DHODHALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL3713520 | 0.86 | GRM5 (0.46) | MAPK1ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL13188472 | 0.86 | MAPT (0.42) | CYP19A1CYP11B1CYP11B2ALDH1A1MEN1 | |
| SCHEMBL3720782 | 0.86 | MEN1 (0.47) | MAPK1CYP19A1CYP11B1CYP11B2ALDH1A1 | |
| SCHEMBL3716537 | 0.86 | MCL1 (0.47) | ALDH1A1MEN1KMT2AKDM4EHPGD | |
| SCHEMBL3712449 | 0.84 | GRM5 (0.44) | MAPK1DHODHCYP11B1CYP11B2ALDH1A1 | |
| SCHEMBL13187704 | 0.83 | NPC1 (0.44) | CYP19A1CYP11B1CYP11B2ALDH1A1MEN1 | |
| SCHEMBL3713522 | 0.79 | GRM5 (0.43) | MAPK1ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL3716967 | 0.79 | ERN1 (0.46) | KMT2ANR4A2KDM4EFFAR1AAK1 | |
| SCHEMBL3709575 | 0.79 | ALDH1A1 (0.47) | CYP19A1CYP11B1CYP11B2ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |