Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13188472 | 0.96 | MAPT (0.42) | MEN1KMT2AALDH1A1TP53MAPT | |
| SCHEMBL13187704 | 0.93 | NPC1 (0.44) | MEN1KMT2AALDH1A1TP53NPC1 | |
| SCHEMBL3709730 | 0.90 | PLA2G2A (0.44) | MEN1KMT2AALDH1A1TP53NPC1 | |
| SCHEMBL13187708 | 0.88 | CSF1R (0.41) | FFAR1CSF1RMMP1MMP9MMP13 | |
| SCHEMBL3712228 | 0.88 | ABCB1 (0.38) | ALDH1A1NPC1RAB9ADHODHCSF1R | |
| SCHEMBL13188547 | 0.86 | MCL1 (0.47) | MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL13188481 | 0.86 | PTGES (0.42) | FFAR1CSF1RMMP1MMP9MMP13 | |
| SCHEMBL13188838 | 0.86 | MAPT (0.40) | MEN1KMT2AALDH1A1TP53NPC1 | |
| SCHEMBL3713520 | 0.81 | GRM5 (0.46) | MEN1KMT2AALDH1A1NPC1RAB9A | |
| SCHEMBL13188521 | 0.80 | ABCB1 (0.44) | ALDH1A1NPC1RAB9AMAPTFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |