Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.41 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL370894 | 0.87 | RARB (0.46) | EGFRMEN1KMT2ATSHRALDH1A1 | |
| SCHEMBL369805 | 0.85 | CYP4A11 (0.50) | EGFRPTGS2MEN1KMT2AALOX12 | |
| SCHEMBL4664597 | 0.81 | EGFR (0.60) | EGFRPTGS2MAPTMEN1KMT2A | |
| SCHEMBL3748237 | 0.78 | EGFR (0.63) | EGFRPTGS2MAPTMEN1KMT2A | |
| SCHEMBL27621631 | 0.78 | EGFR (0.56) | EGFRPTGS2MAPTMEN1KMT2A | |
| SCHEMBL821283 | 0.75 | PTGS2 (0.59) | EGFRPTGS2MAPTMEN1KMT2A | |
| SCHEMBL410454 | 0.75 | EGFR (0.46) | EGFRPTGS2MAPTMEN1KMT2A | |
| SCHEMBL10458005 | 0.75 | PTGS2 (0.76) | EGFRPTGS2MAPTMEN1KMT2A | |
| SCHEMBL11208106 | 0.74 | TAAR1 (0.48) | KMT2AALDH1A1LMNAL3MBTL1TDP1 | |
| SCHEMBL2771823 | 0.74 | PTGS2 (0.59) | EGFRPTGS2MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593426-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012007365-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-19 | — | — | WO | disclosed |