Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 3/20 | 0.55 |
| ▸ | MAOA | P21397 | 1/20 | 0.55 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.55 |
| ▸ | DPP4 | P27487 | 4/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.39 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13922315 | 0.77 | TACR1 (0.58) | SLC6A4TACR1 | |
| SCHEMBL20698822 | 0.75 | MEN1 (0.43) | MAOBMAOATAAR1DPP4OPRM1 | |
| SCHEMBL3017563 | 0.75 | OPRM1 (0.42) | OPRM1OPRL1CXCR3MEN1KMT2A | |
| SCHEMBL3021766 | 0.74 | MEN1 (0.57) | OPRM1OPRL1CXCR3MEN1KMT2A | |
| SCHEMBL10566468 | 0.73 | MAOA (0.62) | MAOBMAOATAAR1DPP4OPRM1 | |
| SCHEMBL1492704 | 0.72 | MAOB (1.00) | MAOBMAOATAAR1DPP4OPRM1 | |
| Ethylene Glycol SCHEMBL3899600 | 0.72 | MAOA (0.61) | MAOBMAOATAAR1DPP4SLC6A4 | |
| SCHEMBL6378173 | 0.72 | OPRM1 (0.40) | MAOBMAOATAAR1DPP4OPRM1 | |
| SCHEMBL15037442 | 0.71 | OPRM1 (0.45) | OPRM1OPRL1CXCR3MEN1KMT2A | |
| SCHEMBL11819360 | 0.71 | TSHR (0.44) | MAOBMAOATAAR1OPRM1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2391603-A1 | AROYLAMINO - AND HETEROAROYLAMINO-SUBSTITUTED PIPERIDINES AS GLYT-1 INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2011-12-07 | — | — | EP | disclosed |
| WO-2010086251-A1 | AROYLAMINO - AND HETEROAROYLAMINO-SUBSTITUTED PIPERIDINES AS GLYT-1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-08-05 | — | — | WO | disclosed |