Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | PDK2 | Q15119 | 4/20 | 0.51 |
| ▸ | FASN | P49327 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | MLNR | O43193 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | F10 | P00742 | 1/20 | 0.39 |
| ▸ | POLQ | O75417 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1522068 | 0.81 | HTT (0.59) | LMNAFASNHTTPKMPOLB | |
| SCHEMBL9001880 | 0.81 | HTT (0.59) | LMNAFASNHTTPKMPOLB | |
| SCHEMBL20982251 | 0.79 | PDK2 (0.80) | PDK2 | |
| SCHEMBL8819827 | 0.77 | PKM (0.59) | LMNAFASNHTTPKMPOLB | |
| SCHEMBL19540938 | 0.76 | USP30 (0.57) | LMNAPDK2PKM | |
| SCHEMBL13841220 | 0.75 | HTT (0.53) | LMNAFASNHTTPKMPOLB | |
| SCHEMBL9001847 | 0.74 | FASN (0.52) | LMNAFASNHTTPKMPOLB | |
| SCHEMBL29273235 | 0.74 | LMNA (0.49) | LMNAFASNHTTPKMPOLB | |
| SCHEMBL2312935 | 0.74 | LMNA (0.49) | LMNAPDK2FASNHTTPKM | |
| SCHEMBL4802576 | 0.74 | LMNA (0.49) | LMNAFASNHTTPKMPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2209376-A1 | NOVEL SEH INHIBITORS AND THEIR USE | GlaxoSmithKline LLC (US) | 2010-07-28 | — | — | EP | disclosed |
| WO-2009049165-A1 | NOVEL SEH INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-04-16 | — | — | WO | disclosed |