Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | MOK | Q9UQ07 | 4/20 | 0.48 |
| ▸ | MMP13 | P45452 | 5/20 | 0.47 |
| ▸ | MMP2 | P08253 | 4/20 | 0.47 |
| ▸ | MMP8 | P22894 | 4/20 | 0.47 |
| ▸ | MMP9 | P14780 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13187973 | 0.94 | HDAC1 (0.55) | HDAC1HDAC3HDAC2HDAC8HDAC6 | |
| SCHEMBL3719071 | 0.89 | MAPK1 (0.49) | MOKMMP13MMP2MMP8MMP9 | |
| SCHEMBL3720406 | 0.87 | HDAC1 (0.52) | HDAC1HDAC3HDAC2HDAC8HDAC6 | |
| SCHEMBL13188496 | 0.87 | HDAC1 (0.48) | HDAC1HDAC3HDAC2HDAC8HDAC6 | |
| SCHEMBL3714261 | 0.86 | DYRK1A (0.54) | HDAC1HDAC3HDAC2HDAC8HDAC6 | |
| SCHEMBL3714253 | 0.85 | HDAC1 (0.52) | HDAC1HDAC3HDAC2HDAC8HDAC6 | |
| SCHEMBL13188498 | 0.85 | HDAC1 (0.49) | HDAC1HDAC3HDAC2HDAC8HDAC6 | |
| SCHEMBL3716223 | 0.84 | ACP1 (0.56) | HDAC1 | |
| SCHEMBL3718122 | 0.84 | MOK (0.48) | HDAC1HDAC3HDAC2HDAC8HDAC6 | |
| SCHEMBL13188784 | 0.82 | HDAC1 (0.51) | HDAC1HDAC3HDAC2HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |