Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 3/20 | 0.42 |
| ▸ | MMP8 | P22894 | 3/20 | 0.42 |
| ▸ | MMP13 | P45452 | 3/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13188396 | 0.94 | DYRK1A (0.57) | DYRK1AHDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL3710585 | 0.91 | DYRK1A (0.53) | DYRK1AJAK2JAK3ALKNPC1 | |
| SCHEMBL3710589 | 0.86 | HDAC1 (0.49) | HDAC1HDAC3HDAC2HDAC8HDAC6 | |
| SCHEMBL13188616 | 0.85 | DYRK1A (0.56) | DYRK1AHDAC1JAK2JAK3NPC1 | |
| SCHEMBL13188496 | 0.82 | HDAC1 (0.48) | HDAC1HDAC3HDAC2HDAC8HDAC6 | |
| SCHEMBL3716108 | 0.81 | LMNA (0.45) | HDAC1HDAC6NPC1RAB9AHIF1A | |
| SCHEMBL3720406 | 0.80 | HDAC1 (0.52) | HDAC1HDAC3HDAC2HDAC8HDAC6 | |
| SCHEMBL3714253 | 0.80 | HDAC1 (0.52) | HDAC1HDAC3HDAC2HDAC8HDAC6 | |
| SCHEMBL3715159 | 0.80 | HDAC1 (0.65) | HDAC1HDAC3HDAC2HDAC8HDAC6 | |
| SCHEMBL13187973 | 0.79 | HDAC1 (0.55) | DYRK1AHDAC1HDAC3HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |