Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 3/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.46 |
| ▸ | PDE4A | P27815 | 2/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 11/20 | 0.46 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.42 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3710011 | 0.87 | PDE4B (0.44) | PDE4BPDE4DPDE4APDE4CGPR119 | |
| SCHEMBL3055131 | 0.85 | GPR119 (0.47) | PDE4BPDE4DPDE4APDE4CGPR119 | |
| SCHEMBL3706690 | 0.84 | KDM1A (0.52) | PDE4BPDE4DPDE4APDE4CGPR119 | |
| SCHEMBL1571126 | 0.84 | GPR119 (0.45) | PDE4BPDE4DPDE4APDE4CGPR119 | |
| SCHEMBL3710674 | 0.83 | GPR119 (0.43) | PDE4BGPR119 | |
| SCHEMBL3713593 | 0.82 | PDE4B (0.43) | PDE4BPDE4DPDE4APDE4CGPR119 | |
| SCHEMBL3715194 | 0.82 | PDE4D (0.47) | PDE4BPDE4DPDE4APDE4CGPR119 | |
| SCHEMBL3717083 | 0.82 | PDE4B (0.43) | PDE4BPDE4DPDE4APDE4CGPR119 | |
| SCHEMBL1318424 | 0.82 | NPBWR1 (0.45) | PDE4BPDE4DPDE4APDE4CGPR119 | |
| SCHEMBL2848570 | 0.80 | BACE1 (0.48) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010094643-A1 | QUINOLINE DERIVATIVES AND THEIR USES FOR RHINITIS AND URTICARIA | GLAXO GROUP LIMITED (GB) | 2010-08-26 | — | — | WO | disclosed |