Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 1/20 | 0.51 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.51 |
| ▸ | ABL1 | P00519 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 6/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.47 |
| ▸ | SCD | O00767 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | ITK | Q08881 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8146900 | 0.85 | ABL1 (0.49) | ABL1MAPTMEN1KMT2ANPC1 | |
| SCHEMBL25909744 | 0.80 | ALDH1A1 (0.54) | PIK3CAPIK3CGABL1MAPTMEN1 | |
| SCHEMBL31472495 | 0.79 | ABL1 (0.48) | PIK3CAPIK3CGABL1MAPTMEN1 | |
| SCHEMBL25644014 | 0.79 | ABL1 (0.48) | PIK3CAPIK3CGABL1MAPTMEN1 | |
| SCHEMBL3782341 | 0.79 | PIK3CG (0.56) | PIK3CAPIK3CGABL1NPC1SCD | |
| SCHEMBL13188404 | 0.79 | ABL1 (0.46) | PIK3CAPIK3CGABL1NPC1RAB9A | |
| SCHEMBL3714334 | 0.78 | PIK3CG (0.44) | PIK3CAPIK3CGABL1MAPTMEN1 | |
| SCHEMBL3706010 | 0.76 | NPC1 (0.48) | MAPTMEN1KMT2ANPC1KDM4E | |
| SCHEMBL19348262 | 0.76 | MAOB (0.51) | PIK3CAPIK3CGMAPTMEN1KMT2A | |
| SCHEMBL2743622 | 0.76 | SCD (0.56) | MAPTMEN1KMT2ANPC1MCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100144-A1 | FUSED BICYCLIC COMPOUNDS AS INHIBITORS FOR PI3 KINASE | MERCK SERONO S.A. (CH) | 2010-09-10 | — | — | WO | disclosed |