Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 12/20 | 0.56 |
| ▸ | PIK3CA | P42336 | 9/20 | 0.53 |
| ▸ | ABL1 | P00519 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | WNT3A | P56704 | 1/20 | 0.42 |
| ▸ | SCD | O00767 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13189215 | 0.88 | KMT2A (0.53) | PIK3CGPIK3CAABL1NPC1RAB9A | |
| SCHEMBL10081131 | 0.82 | RAB9A (0.54) | PIK3CGPIK3CANPC1RAB9ADYRK1A | |
| SCHEMBL3714334 | 0.81 | PIK3CG (0.44) | PIK3CGPIK3CAABL1NPC1RAB9A | |
| SCHEMBL3709559 | 0.81 | PIK3CG (0.83) | PIK3CGPIK3CAABL1 | |
| SCHEMBL13188752 | 0.80 | PIK3CG (0.53) | PIK3CGPIK3CAABL1DYRK1A | |
| SCHEMBL3710786 | 0.79 | PIK3CA (0.51) | PIK3CGPIK3CAABL1NPC1RAB9A | |
| SCHEMBL10080973 | 0.78 | PDE10A (0.50) | PIK3CGPIK3CANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3708514 | 0.77 | PIK3CG (0.47) | PIK3CGPIK3CACYP1A2CYP3A4CYP2C19 | |
| SCHEMBL8146900 | 0.77 | ABL1 (0.49) | ABL1NPC1RAB9ASMN1; SMN2WNT3A | |
| SCHEMBL13188161 | 0.77 | PIK3CG (0.51) | PIK3CGPIK3CAABL1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100144-A1 | FUSED BICYCLIC COMPOUNDS AS INHIBITORS FOR PI3 KINASE | MERCK SERONO S.A. (CH) | 2010-09-10 | — | — | WO | disclosed |