Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 2/20 | 0.58 |
| ▸ | DHODH | Q02127 | 2/20 | 0.52 |
| ▸ | PARP1 | P09874 | 8/20 | 0.52 |
| ▸ | IKBKB | O14920 | 2/20 | 0.49 |
| ▸ | HTR3A | P46098 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.42 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL204764 | 0.97 | TOP2A (0.61) | TOP2ADHODHPARP1IKBKBHTR3A | |
| SCHEMBL206525 | 0.89 | PARP1 (0.52) | TOP2APARP1IKBKBHTR3AKDM4E | |
| SCHEMBL206391 | 0.87 | PARP1 (0.53) | TOP2APARP1IKBKBHTR3A | |
| SCHEMBL205454 | 0.87 | TOP2A (0.48) | TOP2APARP1HTR3AKDM4EHSD17B10 | |
| SCHEMBL206399 | 0.87 | HTR3A (0.53) | TOP2APARP1HTR3AKDM4EHSD17B10 | |
| SCHEMBL204524 | 0.87 | PARP1 (0.53) | TOP2APARP1IKBKBHTR3AKDM4E | |
| SCHEMBL3781416 | 0.87 | PARP1 (0.58) | TOP2ADHODHPARP1IKBKBHSD17B10 | |
| SCHEMBL121325 | 0.86 | TOP2A (0.65) | TOP2ADHODHIKBKBHTR3AKDM4E | |
| SCHEMBL206244 | 0.86 | PKN1 (0.52) | TOP2APARP1HTR3AKDM4EHSD17B10 | |
| SCHEMBL28926584 | 0.85 | TOP2A (0.59) | TOP2ADHODHPARP1HTR3AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110293744-A1 | BENZOXAZOLE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE | ABBOTT LABORATORIES (US) | 2011-12-01 | — | — | US | claimed |
| US-20110293744-A1 | BENZOXAZOLE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE | ABBOTT LABORATORIES (US) | 2011-12-01 | — | — | US | disclosed |
| WO-2010083220-A1 | BENZOXAZOLE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE | ABBOTT LABORATORIES (US) | 2010-07-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110293744-A1 | BENZOXAZOLE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE | PARP1, PARP2, PARP3 | TOP2A 20/4885DHODH 734/4885PARP1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.