Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 2/20 | 0.65 |
| ▸ | DHODH | Q02127 | 2/20 | 0.55 |
| ▸ | HTR3A | P46098 | 1/20 | 0.53 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | IDO1 | P14902 | 1/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 5/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | IKBKB | O14920 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28926584 | 0.95 | TOP2A (0.59) | TOP2ADHODHHTR3ARCE1ALDH1A1 | |
| SCHEMBL16383496 | 0.89 | TOP2A (0.54) | TOP2ADHODHHTR3AALDH1A1IDO1 | |
| SCHEMBL2961027 | 0.89 | TOP2A (0.54) | TOP2ADHODHHTR3ARCE1ALDH1A1 | |
| SCHEMBL204764 | 0.89 | TOP2A (0.61) | TOP2ADHODHHTR3ARCE1ALDH1A1 | |
| SCHEMBL120321 | 0.88 | HTR3A (0.54) | TOP2ADHODHHTR3AALDH1A1IDO1 | |
| SCHEMBL121392 | 0.88 | HTR3A (0.54) | TOP2ADHODHHTR3AALDH1A1IDO1 | |
| SCHEMBL205351 | 0.88 | TOP2A (0.53) | TOP2ADHODHHTR3AALDH1A1IDO1 | |
| SCHEMBL206232 | 0.88 | TOP2A (0.56) | TOP2ADHODHHTR3AALDH1A1IDO1 | |
| SCHEMBL3710917 | 0.86 | TOP2A (0.58) | TOP2ADHODHHTR3ARCE1ALDH1A1 | |
| SCHEMBL7434524 | 0.85 | TOP2A (0.88) | TOP2ADHODHHTR3AALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 122 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100448852-C | Compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding | SCRIPPS RESEARCH INST (US) | 2009-01-07 | — | — | CN | claimed |
| EP-1587821-B1 | COMPOSITIONS AND METHODS FOR STABILIZING TRANSTHYRETIN AND INHIBITING TRANSTHYRETIN MISFOLDING | SCRIPPS RESEARCH INST (US) | 2008-08-20 | — | — | EP | claimed |
| US-7214696-B2 | Compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding | THE SCRIPPS RESEARCH INSTITUTE (US) | 2007-05-08 | — | — | US | claimed |
| US-20060057644-A1 | Compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding | SCRIPPS RESEARCH INSTITUTE, THE | 2006-03-16 | — | — | US | claimed |
| WO-2022107166-A1 | NOVEL CRYSTALLINE FORM OF TAFAMIDIS AND ITS PROCESS THEREOF | NATCO PHARMA LIMITED (IN) | 2022-05-27 | — | — | WO | disclosed |
| US-20160185739-A1 | Solid Forms Of A Transthyretin Dissociation Inhibitor | PFIZER (US) | 2016-06-30 | — | — | US | disclosed |
| CN-103781770-B | Transthyretin dissociates the solid form of inhibitor | PFIZER INC. (US) | 2016-04-13 | — | — | CN | disclosed |
| US-9249112-B2 | Solid forms of a transthyretin dissociation inhibitor | PFIZER INC. (US) | 2016-02-02 | — | — | US | disclosed |
| EP-2611774-B1 | DI-AZETIDINYL DIAMIDE AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-03-18 | — | — | EP | disclosed |
| US-8962607-B2 | Azetidinyl diamides as monoacylglycerol lipase inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2015-02-24 | — | — | US | disclosed |
| US-8962607-B2 | Azetidinyl diamides as monoacylglycerol lipase inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2015-02-24 | — | — | US | disclosed |
| US-20150031735-A1 | SOLID FORMS OF A TRANSTHYRETIN DISSOCIATION INHIBITOR | PFIZER (US) | 2015-01-29 | — | — | US | disclosed |
| WO-2006089100-A1 | BENZOXAZOLE CARBOXAMIDES FOR TREATING CINV AND IBS-D | AMR TECHNOLOGY, INC. (US) | 2006-08-24 | — | — | WO | disclosed |
| US-20060183769-A1 | Benzoxazole carboxamides for treating CINV and IBS-D | AMR TECHNOLOGY, INC. (US) | 2006-08-17 | — | — | US | disclosed |
| US-20060057644-A1 | Compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding | SCRIPPS RESEARCH INSTITUTE, THE | 2006-03-16 | — | — | US | disclosed |
| CN-1747965-A | Compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding | SCRIPPS RESEARCH INST (US) | 2006-03-15 | — | — | CN | disclosed |
| EP-1587821-A2 | COMPOSITIONS AND METHODS FOR STABILIZING TRANSTHYRETIN AND INHIBITING TRANSTHYRETIN MISFOLDING | The Scripps Research Institute (US) | 2005-10-26 | — | — | EP | disclosed |
| US-20040152140-A1 | Compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding | THE SCRIPPS RESEARCH INSTITUTE | 2004-08-05 | — | — | US | disclosed |
| WO-2004056315-A2 | COMPOSITIONS AND METHODS FOR STABILIZING TRANSTHYRETIN AND INHIBITING TRANSTHYRETIN MISFOLDING | THE SCRIPPS RESEARCH INSTITUTE (US) | 2004-07-08 | — | — | WO | disclosed |
| EP-0749415-A1 | BENZAMIDE ANALOGS, USEFUL AS PARP (ADP-RIBOSYLTRANSFERASE, ADPRT) DNA REPAIR ENZYME INHIBITORS | NEWCASTLE UNIVERSITY VENTURES LIMITED (GB) | 1996-12-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060183769-A1 | Benzoxazole carboxamides for treating CINV and IBS-D | HTR3E, BRS3, HTR3A | TOP2A 1421/4885DHODH 2821/4885HTR3A 3/4885 |
| US-20150031735-A1 | SOLID FORMS OF A TRANSTHYRETIN DISSOCIATION INHIBITOR | TTR, TPMT, TTPA | TOP2A 1131/4885DHODH 773/4885HTR3A 4362/4885 |
| US-20160185739-A1 | Solid Forms Of A Transthyretin Dissociation Inhibitor | TTR, TPMT, TTPA | TOP2A 1131/4885DHODH 773/4885HTR3A 4362/4885 |
| US-20060057644-A1 | Compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding | TTR, TTPA, PRNP | TOP2A 1658/4885DHODH 1409/4885HTR3A 4510/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.