Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.30 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28112798 | 0.85 | HTR6 (0.38) | TDP1KMT2APKMCHRM5 | |
| SCHEMBL1881164 | 0.83 | TDP1 (0.39) | TDP1KMT2APKMMEN1CHRM5 | |
| SCHEMBL18639116 | 0.78 | LMNA (0.35) | TDP1KMT2AMEN1CYP2C19TSHR | |
| SCHEMBL1862645 | 0.77 | TDP1 (0.41) | TDP1 | |
| SCHEMBL1869887 | 0.77 | TDP1 (0.41) | TDP1 | |
| SCHEMBL18638800 | 0.74 | S1PR1 (0.40) | TDP1KMT2AMEN1CYP3A4CYP2C9 | |
| SCHEMBL12603802 | 0.73 | CYP1A2 (0.31) | TDP1CHRM5ADRA2C | |
| SCHEMBL26015519 | 0.73 | CXCR4 (0.45) | KMT2AMEN1 | |
| SCHEMBL4034937 | 0.72 | AGL (0.36) | TDP1KMT2APKMOPRM1OPRL1 | |
| SCHEMBL4085257 | 0.71 | CXCR4 (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2211618-A1 | PIPERIDINYLHYDROXYETHYLPIPERIDINES AS MODULATORS OF CHEMOKINE RECEPTORS | Glaxo Group Limited (GB) | 2010-08-04 | — | — | EP | disclosed |
| WO-2009049113-A1 | PIPERIDINYLHYDROXYETHYLPIPERIDINES AS MODULATORS OF CHEMOKINE RECEPTORS | GLAXO GROUP LIMITED (GB) | 2009-04-16 | — | — | WO | disclosed |