Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Remifentanil. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 14/20 | 0.76 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.98 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.76 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Remifentanil SCHEMBL41242 | 1.00 | CACNA1C (0.98) | CACNA1COPRM1OPRD1OPRK1 | |
| Remifentanil SCHEMBL3423820 | 1.00 | CACNA1C (0.98) | CACNA1COPRM1OPRD1OPRK1 | |
| Remifentanil SCHEMBL29846323 | 1.00 | CACNA1C (0.98) | CACNA1COPRM1OPRD1OPRK1 | |
| Remifentanil SCHEMBL36652 | 0.99 | CACNA1C (1.00) | CACNA1COPRM1OPRD1OPRK1 | |
| Remifentanil SCHEMBL17874058 | 0.99 | CACNA1C (1.00) | CACNA1COPRM1OPRD1OPRK1 | |
| Remifentanil SCHEMBL27828413 | 0.97 | CACNA1C (0.96) | CACNA1COPRM1OPRD1OPRK1 | |
| Remifentanil SCHEMBL1649640 | 0.97 | CACNA1C (0.96) | CACNA1COPRM1OPRD1OPRK1 | |
| Remifentanil SCHEMBL8446617 | 0.94 | CACNA1C (0.90) | CACNA1COPRM1OPRD1OPRK1 | |
| Carfentanil SCHEMBL16444962 | 0.93 | OPRM1 (0.89) | CACNA1COPRM1OPRD1OPRK1 | |
| Remifentanil SCHEMBL4384648 | 0.93 | CACNA1C (0.89) | CACNA1COPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10117862-B2 | Remifentanil injection | TERUMO KABUSHIKI KAISHA (JP) | 2018-11-06 | — | — | US | disclosed |
| US-20170182019-A1 | Remifentanil Injection | TERUMO KABUSHIKI KAISHA (KZ) | 2017-06-29 | — | — | US | disclosed |
| WO-2010098897-A1 | NARCOTIC EMULSION FORMULATIONS FOR TREATMENT OF CANCER PAIN | TEIKOKU PHARMA USA, INC. (US) | 2010-09-02 | — | — | WO | disclosed |