Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13188251 | 0.88 | CSF1R (0.45) | ERN1CSF1RAAK1KDM4EPTGDR2 | |
| SCHEMBL3711387 | 0.87 | AAK1 (0.45) | ERN1ALDH1A1CSF1RAAK1KDM4E | |
| SCHEMBL3711323 | 0.85 | AAK1 (0.45) | ERN1ALDH1A1CSF1RAAK1KDM4E | |
| SCHEMBL3711431 | 0.80 | CSF1R (0.53) | ERN1ALDH1A1CSF1RAAK1KDM4E | |
| SCHEMBL25294855 | 0.80 | ALDH1A1 (0.51) | ERN1ALDH1A1CSF1RAAK1PTGDR2 | |
| SCHEMBL3711926 | 0.79 | ALDH1A1 (0.44) | ERN1ALDH1A1CSF1RAAK1KDM4E | |
| SCHEMBL3714223 | 0.79 | ALDH1A1 (0.62) | ERN1ALDH1A1CSF1RKDM4EKMT2A | |
| SCHEMBL3714907 | 0.78 | MAPT (0.50) | ALDH1A1 | |
| SCHEMBL5781938 | 0.77 | NR4A2 (0.54) | ALDH1A1KDM4EGABRA1GABRG2GABRB3 | |
| SCHEMBL26101255 | 0.77 | ALDH1A1 (0.40) | ALDH1A1KDM4EGRM5CYP2C9CHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |