Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | PIK3CA | P42336 | 10/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.43 |
| ▸ | PLOD3 | O60568 | 1/20 | 0.43 |
| ▸ | PLOD1 | Q02809 | 1/20 | 0.43 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13188148 | 0.87 | PIK3CA (0.46) | MAPTPIK3CAPLOD2PLOD3PLOD1 | |
| SCHEMBL17478867 | 0.80 | ALDH1A1 (0.60) | OPRK1ALDH1A1LRRK2 | |
| SCHEMBL3715549 | 0.79 | OPRK1 (0.44) | OPRK1ALDH1A1 | |
| SCHEMBL3711230 | 0.78 | ERN1 (0.46) | ALDH1A1 | |
| SCHEMBL16105029 | 0.76 | OPRK1 (0.61) | MAPTOPRK1ALDH1A1 | |
| SCHEMBL3711323 | 0.76 | AAK1 (0.45) | ALDH1A1 | |
| SCHEMBL3713658 | 0.75 | OPRK1 (0.40) | OPRK1 | |
| SCHEMBL3719404 | 0.74 | OPRK1 (0.75) | OPRK1 | |
| SCHEMBL29574379 | 0.74 | OPRK1 (0.75) | OPRK1 | |
| SCHEMBL3714505 | 0.73 | PIK3CA (0.48) | MAPTPIK3CAPLOD2PLOD3PLOD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |