SCHEMBL3711432

SCHEMBL3711432

O=C(NO)c1cncc(-c2ccc(Oc3ccccc3)cc2)c1

nearest known ligand 0.56

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
HDAC8 Q9BY41 3/20 0.56
HDAC1 Q13547 5/20 0.56
KDM1A O60341 3/20 0.56
XDH P47989 3/20 0.51
SCN10A Q9Y5Y9 2/20 0.50
SCN2A Q99250 1/20 0.50
SMPD1 P17405 2/20 0.49
KAT6A Q92794 1/20 0.49
SLC22A12 Q96S37 1/20 0.49
BCL2L1 Q07817 2/20 0.48
MCL1 Q07820 2/20 0.48
HDAC6 Q9UBN7 1/20 0.48
CTSA P10619 1/20 0.47
MKNK1 Q9BUB5 1/20 0.46
MKNK2 Q9HBH9 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13187778 0.87 HDAC8 (0.64) HDAC8HDAC1KDM1AXDHSCN10A
SCHEMBL13741926 0.84 SCN2A (0.55) HDAC1KDM1AXDHSCN10ASCN2A
SCHEMBL3713278 0.83 CYP11B1 (0.64) XDHSCN10ASLC22A12MCL1CTSA
SCHEMBL3716705 0.83 SMPD1 (0.62) HDAC8HDAC1KDM1ASCN10ASCN2A
SCHEMBL1758508 0.83 MKNK1 (0.63) XDHSLC22A12MKNK1MKNK2
SCHEMBL13188758 0.78 HDAC1 (0.63) HDAC8HDAC1KDM1ASMPD1HDAC6
SCHEMBL1315924 0.78 GALK1 (0.52) XDHSLC22A12MCL1
SCHEMBL443547 0.77 NPC1 (0.65) HDAC1KDM1ASCN10ASCN2AHDAC6
SCHEMBL13188893 0.77 HDAC6 (0.52) HDAC8HDAC1KDM1AXDHSCN10A
SCHEMBL13188232 0.77 HDAC8 (0.71) HDAC8HDAC1BCL2L1MCL1HDAC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010100475-A1 HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS ASTRAZENECA AB (SE) 2010-09-10 WO disclosed
WO-2010100475-A1 HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS ASTRAZENECA AB (SE) 2010-09-10 WO disclosed