Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMPD1 | P17405 | 9/20 | 0.62 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.56 |
| ▸ | KDM1A | O60341 | 2/20 | 0.56 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.54 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | APP | P05067 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.50 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.50 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3711921 | 0.85 | CYP11B1 (0.57) | SMPD1SCN2ASCN10ARAB9ASIRT2 | |
| SCHEMBL3711432 | 0.83 | HDAC8 (0.56) | SMPD1HDAC1KDM1ASCN2ASCN10A | |
| SCHEMBL13187778 | 0.81 | HDAC8 (0.64) | HDAC1KDM1ASCN2ASCN10AKAT6A | |
| SCHEMBL443547 | 0.79 | NPC1 (0.65) | HDAC1KDM1ASCN2ASCN10ARAB9A | |
| SCHEMBL5944125 | 0.79 | SMPD1 (0.79) | SMPD1HDAC1HDAC4HDAC8HDAC6 | |
| SCHEMBL3713068 | 0.78 | HDAC1 (0.82) | SMPD1HDAC1KDM1ARAB9AKAT6A | |
| SCHEMBL31418277 | 0.78 | ALDH1A1 (0.51) | SMPD1SCN2ASCN10ARAB9ASIRT2 | |
| SCHEMBL3715274 | 0.78 | SMPD1 (0.67) | SMPD1HDAC1 | |
| SCHEMBL10839211 | 0.77 | SMPD1 (0.74) | SMPD1HDAC1HDAC3APPACHE | |
| SCHEMBL1608032 | 0.76 | SMPD1 (1.00) | SMPD1HDAC1HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |