Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | NQO2 | P16083 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4270611 | 0.85 | KDM4E (0.44) | ALDH1A1KDM4EL3MBTL1LMNACYP1A2 | |
| SCHEMBL15020087 | 0.82 | ALDH1A1 (0.55) | ALDH1A1KDM4EL3MBTL1LMNATDP1 | |
| SCHEMBL2897680 | 0.80 | LMNA (0.71) | ALDH1A1KDM4EL3MBTL1LMNATDP1 | |
| SCHEMBL9423136 | 0.80 | ALDH1A1 (0.56) | ALDH1A1KDM4EL3MBTL1LMNATDP1 | |
| SCHEMBL4038668 | 0.79 | ALDH1A1 (0.55) | ALDH1A1KDM4EL3MBTL1LMNATDP1 | |
| SCHEMBL1760242 | 0.79 | ALDH1A1 (0.55) | ALDH1A1KDM4EL3MBTL1LMNATDP1 | |
| SCHEMBL31229792 | 0.77 | ALDH1A1 (0.53) | ALDH1A1KDM4EL3MBTL1LMNATDP1 | |
| SCHEMBL4038801 | 0.77 | ALDH1A1 (0.53) | ALDH1A1KDM4EL3MBTL1LMNATDP1 | |
| SCHEMBL4038797 | 0.77 | ALDH1A1 (0.53) | ALDH1A1KDM4EL3MBTL1LMNATDP1 | |
| SCHEMBL15019512 | 0.76 | KDM4E (0.56) | ALDH1A1KDM4EL3MBTL1LMNATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |