Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 6/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | ILK | Q13418 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | MMP13 | P45452 | 1/20 | 0.35 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3572338 | 0.68 | GPR35 (0.55) | PARP1DYRK1AILKTSHR | |
| SCHEMBL5327647 | 0.64 | PARP1 (0.39) | KDM4EGLAPARP1DYRK1ATDP1 | |
| SCHEMBL29503140 | 0.64 | PRSS1 (0.61) | PARP1TDP1KMT2ALCKALDH1A1 | |
| SCHEMBL1002832 | 0.64 | PRSS1 (0.61) | PARP1TDP1KMT2ALCKALDH1A1 | |
| SCHEMBL24052275 | 0.63 | NPC1 (0.76) | DYRK1AKMT2AALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL30507791 | 0.63 | KDM4E (0.50) | KDM4EGLAPARP1TDP1KMT2A | |
| SCHEMBL8574737 | 0.63 | DYRK1A (0.62) | KDM4EDYRK1ATDP1KMT2AILK | |
| SCHEMBL25278485 | 0.62 | PARP1 (0.40) | KDM4EPARP1DYRK1ATDP1LCK | |
| SCHEMBL2128609 | 0.62 | PARP1 (0.52) | KDM4EPARP1TDP1LCKBRD4 | |
| SCHEMBL9541786 | 0.62 | PARP1 (0.52) | KDM4EPARP1KMT2ALCKBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010080397-A1 | SULFAMIDES AS TRPM8 MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2010-07-15 | — | — | WO | disclosed |