Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 6/20 | 0.33 |
| ▸ | GCGR | P47871 | 3/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.30 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.30 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3105773 | 0.80 | PPARD (0.40) | GCGRDPP4CNR1 | |
| SCHEMBL3711570 | 0.78 | MALT1 (0.36) | GCGRDPP4CNR1S1PR1 | |
| SCHEMBL3108345 | 0.73 | PPARD (0.41) | GCGRDPP4CNR1 | |
| SCHEMBL3113330 | 0.72 | DDR1 (0.41) | GCGRDPP4CNR1 | |
| SCHEMBL3100310 | 0.70 | EPHX2 (0.40) | GCGRDPP4CNR1 | |
| SCHEMBL3100296 | 0.66 | DDR1 (0.45) | GCGRDPP4CNR1 | |
| SCHEMBL3111104 | 0.65 | DDR1 (0.44) | GCGRDPP4CNR1 | |
| SCHEMBL3107244 | 0.65 | PPARD (0.44) | GCGRDPP4CNR1 | |
| SCHEMBL4032322 | 0.64 | CRHR1 (0.38) | — | |
| SCHEMBL3114614 | 0.64 | DDR1 (0.44) | CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2209768-A1 | 5,6-DIARYL PYRIDINES SUBSTITUTED IN THE 2- AND 3-POSITION, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2010-07-28 | — | — | EP | disclosed |
| WO-2009087285-A1 | 5,6-DIARYL PYRIDINES SUBSTITUTED IN THE 2- AND 3-POSITION, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2009-07-16 | — | — | WO | disclosed |