Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.53 |
| ▸ | CCR1 | P32246 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | CCR5 | P51681 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | PRNP | P04156 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | NSD1 | Q96L73 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
| ▸ | CTSH | P09668 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7186476 | 0.80 | NPSR1 (0.52) | METAP2CCR1RAB9ACCR5HPGD | |
| SCHEMBL3275027 | 0.80 | METAP2 (0.57) | METAP2CCR1RAB9ACCR5HPGD | |
| SCHEMBL729647 | 0.78 | METAP2 (0.55) | METAP2CCR1RAB9ACCR5LMNA | |
| SCHEMBL11624013 | 0.77 | CCR1 (0.46) | METAP2CCR1RAB9ACCR5HPGD | |
| SCHEMBL2119502 | 0.77 | CCR1 (0.46) | METAP2CCR1RAB9ACCR5HPGD | |
| SCHEMBL20515390 | 0.74 | CCR1 (0.43) | METAP2CCR1RAB9ACCR5HPGD | |
| SCHEMBL16533303 | 0.73 | METAP2 (0.49) | METAP2CCR1RAB9ACCR5HPGD | |
| SCHEMBL2877880 | 0.73 | METAP2 (0.49) | METAP2CCR1RAB9ACCR5LMNA | |
| SCHEMBL29923566 | 0.73 | RAB9A (0.42) | CCR1RAB9ACCR5NPSR1KMT2A | |
| SCHEMBL1617143 | 0.72 | METAP2 (0.57) | METAP2CCR1RAB9ACCR5HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010094643-A1 | QUINOLINE DERIVATIVES AND THEIR USES FOR RHINITIS AND URTICARIA | GLAXO GROUP LIMITED (GB) | 2010-08-26 | — | — | WO | disclosed |