Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 7/20 | 0.35 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.35 |
| ▸ | HTR3B | O95264 | 1/20 | 0.35 |
| ▸ | HTR3A | P46098 | 1/20 | 0.35 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.35 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.35 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 6/20 | 0.33 |
| ▸ | HTR2A | P28223 | 3/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.32 |
| ▸ | PIK3R2 | O00459 | 3/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.32 |
| ▸ | PIK3R5 | Q8WYR1 | 3/20 | 0.32 |
| ▸ | PIK3R3 | Q92569 | 3/20 | 0.32 |
| ▸ | NAAA | Q02083 | 1/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21040531 | 0.84 | HTR2C (0.39) | HTR2BHTR2CHTR2A | |
| SCHEMBL23187488 | 0.83 | F10 (0.32) | PIK3CD | |
| SCHEMBL15972321 | 0.81 | DGAT1 (0.38) | PIK3CDMAPK1 | |
| SCHEMBL1976258 | 0.80 | F10 (0.35) | PARP1HTR2BHTR2CHTR2APIK3CD | |
| SCHEMBL7886958 | 0.80 | MEN1 (0.39) | MAPK1 | |
| Hydrochloric Acid SCHEMBL3565110 | 0.79 | F10 (0.34) | PARP1HTR2BHTR2CHTR2APIK3CD | |
| SCHEMBL29333188 | 0.78 | NAAA (0.44) | PARP1HTR2BHTR3EHTR3BHTR3A | |
| SCHEMBL29332336 | 0.78 | NAAA (0.44) | PARP1HTR2BHTR3EHTR3BHTR3A | |
| SCHEMBL29865291 | 0.77 | F10 (0.38) | PIK3CDIRAK4 | |
| SCHEMBL24710626 | 0.77 | HTR2C (0.41) | PARP1HTR2BHTR3EHTR3BHTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010091721-A1 | 3 -SUBSTITUTED 1-ARYLSULFONYLPIPERIDINE DERIVATIVES FOR THE TREATMENT OF PAIN | GLAXO GROUP LIMITED (GB) | 2010-08-19 | — | — | WO | disclosed |
| WO-2010091721-A1 | 3 -SUBSTITUTED 1-ARYLSULFONYLPIPERIDINE DERIVATIVES FOR THE TREATMENT OF PAIN | GLAXO GROUP LIMITED (GB) | 2010-08-19 | — | — | WO | disclosed |