Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | KDM1A | O60341 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | ITK | Q08881 | 1/20 | 0.42 |
| ▸ | ACP1 | P24666 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3720719 | 0.90 | KMO (0.45) | ACACBKDM1AHDAC1BCHEMAOA | |
| SCHEMBL13187705 | 0.90 | HDAC1 (0.55) | ACACBKDM1AHDAC1 | |
| SCHEMBL13187744 | 0.88 | HDAC1 (0.51) | KDM1AHDAC1 | |
| SCHEMBL3712071 | 0.87 | GAA (0.46) | ACACBSMN1; SMN2KDM1AHDAC1BCHE | |
| SCHEMBL3717935 | 0.86 | MAPK1 (0.50) | MAPK1SMN1; SMN2KMT2AACP1 | |
| SCHEMBL13187707 | 0.85 | HDAC1 (0.48) | KDM1AHDAC1KMT2A | |
| SCHEMBL3713318 | 0.85 | KMT2A (0.46) | MAPK1SMN1; SMN2KMT2AITKACP1 | |
| SCHEMBL3711313 | 0.85 | MAPK1 (0.49) | MAPK1SMN1; SMN2KMT2AACP1 | |
| SCHEMBL3720383 | 0.84 | AURKA (0.46) | ACACBMAPK1SMN1; SMN2KMT2AACP1 | |
| SCHEMBL3710611 | 0.84 | ACACB (0.47) | ACACBMAPK1SMN1; SMN2KDM1AHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |